Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Twelve years of fluconazole in clinical practice: Global-trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida
Clinical Microbiology and Infection, Volume 10, No. SUPPL. 1, Year 2004
Notification
URL copied to clipboard!
Description
We determined the species distribution and in-vitro susceptibility of 6082 bloodstream infection (BSI) isolates of Candida spp. collected from 250 medical centres in 32 nations over a 10-year period from 1992 through 2001. The species included 3401 C. albicans, 984 C. glabrata, 796 C. parapsilosis, 585 C. tropicalis, 153 C. krusei, 67 C. lusitaniae, 48 C. guilliermondii, 10 C. famata, 10 C. kefyr, six C. pelliculosa, five C. rugosa, four C. lipolytica, three C. dubliniensis, three C. inconspicua, two C. sake and one isolate each of C. lambica, C. norvegensis and C. zeylanoides. Minimum inhibitory concentration determinations were made using the National Committee for Clinical Laboratory Standards reference broth microdilution method. Variation in the rank order and frequency of the different species of Candida was observed over time and by geographic area. The proportion of BSI due to C. albicans and C. glabrata increased and C. parapsilosis decreased over time in Canada, the USA and Europe. C. glabrata was an infrequent cause of BSI in Latin America and the Asia-Pacific region. Very little variation in fluconazole susceptibility was observed among isolates of C. albicans, C. tropicalis and C. parapsilosis. These species accounted for 78% of all BSI and remained highly susceptible (91-100% susceptible) to fluconazole from 1992 to 2001 irrespective of geographic origin. The prevalence of fluconazole resistance among C. glabrata isolates was variable both over time and among the various countries and regions. Resistance to fluconazole among C. glabrata isolates was greatest in the USA and varied by US census region (range 0-23%). These observations are generally encouraging relative to the sustained usefulness of fluconazole as a systemically active antifungal agent for the treatment of candida BSI. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
Authors & Co-Authors
Pfaller, Michael A.
Unknown Affiliation
Diekema, D. J.
Unknown Affiliation
Steele-Moore, L.
Unknown Affiliation
Denys, Gerald A.
Unknown Affiliation
Staley, C.
Unknown Affiliation
DiPersio, Joseph R.
Unknown Affiliation
Saubolle, M.
Unknown Affiliation
Wilson, Michael L.
Unknown Affiliation
Overturf, Gary D.
Unknown Affiliation
Peterson, Lance R.
Unknown Affiliation
Schreckenberger, Paul C.
Unknown Affiliation
Doern, G. V.
Unknown Affiliation
Cavalieri, S.
Unknown Affiliation
Kehl, S.
Unknown Affiliation
Brecher, Stephen M.
Unknown Affiliation
Lee, L.
Unknown Affiliation
Isenberg, H.
Unknown Affiliation
Hardy, D.
Unknown Affiliation
Koga, D. S.
Unknown Affiliation
Fusco, Joan
Unknown Affiliation
Hoffmann, M.
Unknown Affiliation
Swanzy, S.
Unknown Affiliation
Murray, Patrick R.
Unknown Affiliation
Southern, P.
Unknown Affiliation
Wanger, Audrey R.
Unknown Affiliation
Reisner, B.
Unknown Affiliation
Snyder, James Walter
Unknown Affiliation
Jenkin, S.
Unknown Affiliation
Hazen, Kevin C.
Unknown Affiliation
Rennie, Robert
Unknown Affiliation
Hoban, Daryl J.
Unknown Affiliation
Davidson, Ross J.
Unknown Affiliation
Toye, Baldwin W.
Unknown Affiliation
Simor, Andrew E.
Unknown Affiliation
Richardson, S.
Unknown Affiliation
Robson, H.
Unknown Affiliation
Smayvsky, J.
Unknown Affiliation
Casellas, José María
Unknown Affiliation
Sampaio, J. L.M.
Unknown Affiliation
Prado, Valeria
Unknown Affiliation
Garcia, Patricia
Unknown Affiliation
Robledo, J.
Unknown Affiliation
Sifuentes-Osornio, José
Unknown Affiliation
Zoccoli, C.
Unknown Affiliation
Reis, A.
Unknown Affiliation
Guzmán, Manuel
Unknown Affiliation
Schwab, D. A.
Unknown Affiliation
Carroll, Karen Colleen
Unknown Affiliation
Chapin-Robertson, K.
Unknown Affiliation
Bourbeau, P.
Unknown Affiliation
Sharp, S. E.
Unknown Affiliation
Barth, Afonso Luís
Unknown Affiliation
Struelens, Marc J.
Unknown Affiliation
Jarlier, Vincent Pascal
Unknown Affiliation
Nguyen, J.
Unknown Affiliation
Roussel-Delvallez, Micheline
Unknown Affiliation
Legakis, N.
Unknown Affiliation
Keller, Nathan
Unknown Affiliation
Pascual, Álvaro
Unknown Affiliation
Liñares, J. P.
Unknown Affiliation
Cantón, Rafael
Unknown Affiliation
Prapian, F.
Unknown Affiliation
Bille, Jacques
Unknown Affiliation
Gu¨r, Deniz
Unknown Affiliation
Korten, Volkan
Unknown Affiliation
Mülazımoğlu, Lütfiye G.
Unknown Affiliation
Unal, Serhat
Unknown Affiliation
Kocagöz, Sesin
Unknown Affiliation
Debbia, E.
Unknown Affiliation
French, Gary
Unknown Affiliation
Étienne, Jérôme
Unknown Affiliation
Raponi, G.
Unknown Affiliation
Rankin, I.
Unknown Affiliation
Nicoletti, G.
Unknown Affiliation
Fadda, Giovanni Maria
Unknown Affiliation
Hanberger, Häkan
Unknown Affiliation
Rangel-Fausto, S.
Unknown Affiliation
Rodloff, Arne Christian
Unknown Affiliation
Smyth, E. T.M.
Unknown Affiliation
Christiansen, Keryn J.
Unknown Affiliation
Coombs, Geoffrey W.
Unknown Affiliation
Kohno, Shigeru
Unknown Affiliation
Miyazaki, Yoshitsugu
Unknown Affiliation
Schmitz, F. J.
Unknown Affiliation
Fluit, A. C.
Unknown Affiliation
Costa, D.
Unknown Affiliation
Appelbaum, Peter Colin
Unknown Affiliation
Bruckner, David A.
Unknown Affiliation
Chaturvedi, Vishnu P.
Unknown Affiliation
Hall, Geraldine S.
Unknown Affiliation
Kauffman, Carol A.
Unknown Affiliation
Sobel, I.
Unknown Affiliation
Suh, B.
Unknown Affiliation
Van Horn, K.
Unknown Affiliation
Finquelievich, Jorge Luis
Unknown Affiliation
Tiraboschi, I. N.
Unknown Affiliation
Colombo, Arnaldo Lopes
Unknown Affiliation
Crewe-Brown, Heather H.
Unknown Affiliation
Roditi, Denise O.J.
Unknown Affiliation
Statistics
Citations: 417
Authors: 99
Affiliations: 97
Identifiers
Doi:
10.1111/j.1470-9465.2004.t01-1-00844.x
ISSN:
1198743X
Study Design
Cross Sectional Study