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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Early clinical markers of overweight/obesity onset and resolution by adolescence
International Journal of Obesity, Volume 44, No. 1, Year 2020
Notification
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Description
Objectives: We examined how combinations of clinical indicators at various ages predict overweight/obesity development, as well as resolution, by 10–11 and 14–15 years of age. Methods: Data were derived from Birth (N = 3469) and Kinder (N = 3276) cohorts of the Longitudinal Study of Australian Children, followed from ages 2–3 and 4–5 years, respectively. Every two years, 25 potential obesity-relevant clinical indicators were quantified. Overweight/obesity was defined using International Obesity Taskforce cutpoints at 10–11 years and 14–15 years. Results: In both cohorts, three factors predicted both development and resolution of overweight/obesity in multivariable models. Among normal weight children, increased odds of developing overweight/obesity were associated with higher child (odd ratio (OR) 1.67–3.35 across different study waves) and maternal (OR 1.05–1.09) BMI, and inversely with higher maternal education (OR 0.60–0.62, when assessed at age 2–7 years). Lower odds of resolving existing overweight/obesity were related with higher child (OR 0.51–0.79) and maternal (OR 0.89–0.95) BMI, and inversely with higher maternal education (OR 1.62–1.92, when assessed at age 2–5 years). The prevalence of overweight/obesity at the age of 14–15 years was 13% among children with none of these risk factors at age 6–7 years, compared with 71% among those with all 3 risk factors (P < 0.001). Conclusions: From early childhood onwards, child and maternal BMI and maternal education predict overweight/obesity onset and resolution by adolescence. A simple risk score, easily available to child health clinicians, could help target treatment or prevention. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
Authors & Co-Authors
Juonala, Markus T.
Finland, Turku
Turun Yliopisto
Finland, Turku
Turun Yliopistollinen Keskussairaala
Australia, Melbourne
Murdoch Children's Research Institute
Grobler, Anneke C.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
Kerr, Jessica A.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
Magnussen, Costan G.
Australia, Hobart
University of Tasmania
Finland, Turku
Turun Yliopisto
Burgner, David Paul
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Royal Children's Hospital, Melbourne
Statistics
Citations: 10
Authors: 5
Affiliations: 7
Identifiers
Doi:
10.1038/s41366-019-0457-2
ISSN:
03070565
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative