Piperogalin, a new prenylated diphenol from peperomia galioides

A petroleum ether extract of Peperomia galioides showed significant in vitro activity against three Leishmania species and Trypanosoma cruzi. Three major prenylated diphenols, including two known compounds, grifolic acid [1], and grifolin [2], and the new substance piperogalin [3], have been isolated. Structures were established on the basis of spectral analysis including 2D nmr spectroscopy. © 1995, American Chemical Society. All rights reserved.