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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium
Genome Research, Volume 15, No. 1, Year 2005
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Description
The advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase of human evolutionary studies. Even quite limited volumes of complete mtDNA sequence data can now be used to identify the critical polymorphisms that define sub-clades within an mtDNA haplogroup, providing a springboard for large-scale high-resolution screening of human mtDNAs. This strategy has in the past been applied to mtDNA haplogroup V, which represents <5% of European mtDNAs. Here we adopted a similar approach to haplogroup H, by far the most common European haplogroup, which at lower resolution displayed a rather uninformative frequency distribution within Europe. Using polymorphism information derived from the growing complete mtDNA sequence database, we sequenced 1580 base pairs of targeted coding-region segments of the mtDNA genome in 649 individuals harboring mtDNA haplogroup H from populations throughout Europe, the Caucasus, and the Near East. The enhanced genealogical resolution clearly shows that sub-clades of haplogroup H have highly distinctive geographical distributions. The patterns of frequency and diversity suggest that haplogroup H entered Europe from the Near East ∼20,000-25,000 years ago, around the time of the Last Glacial Maximum (LGM), and some sub-clades re-expanded from an Iberian refugium when the glaciers retreated ∼15,000 years ago. This shows that a large fraction of the maternal ancestry of modern Europeans traces back to the expansion of hunter-gatherer populations at the end of the last Ice Age. © 2005 by Cold Spring Harbor Laboratory Press.
Authors & Co-Authors
Pereira, Luísa
Portugal, Porto
Universidade do Porto
Richards, Martin B.
United Kingdom, Leeds
University of Leeds
Goios, Ana
Portugal, Porto
Universidade do Porto
Alonso, Antonio
Spain, Madrid
Sección de Biología
Albarrán, Cristina
Spain, Madrid
Sección de Biología
Garcia, Oscar
Spain, Bilbao
Area de Laboratorio Ertzaintza
Behar, Doron M.
Israel, Haifa
Rambam Health Care Campus Israel
Gölge, Mukaddes
Germany, Kiel
Christian-albrechts-universität zu Kiel
Hatina, Jiří
Czech Republic, Prague
Všeobecná Fakultní Nemocnice V Praze
Al-Gazali, Lihadh I.
United Arab Emirates, Al Ain
United Arab Emirates University
B̀radley, Daniel G.
Ireland, Dublin
Trinity College Dublin
MacAulay, Vincent A.
United Kingdom, Glasgow
University of Glasgow
Amorim, Antonio
Portugal, Porto
Universidade do Porto
Statistics
Citations: 13
Authors: 13
Affiliations: 10
Identifiers
Doi:
10.1101/gr.3182305
ISSN:
10889051
Research Areas
Genetics And Genomics
Maternal And Child Health