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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production
Genes and Immunity, Volume 3, No. 7, Year 2002
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Description
Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in Tanzanian children having cerebral malaria but not in Kenyan children with severe malaria. Furthermore, homozygotes for the IL12B promoter polymorphism had decreased production of nitric oxide, which is in part regulated by IL-12 activity. These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population. © 2002 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Morahan, Grant E.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Australia, Melbourne
Royal Melbourne Hospital
Boutlis, Craig Steven
Australia, Darwin
Menzies School of Health Research
Huang, D.
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Pain, Arnab P.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Saunders, J. R.
Australia, Darwin
Menzies School of Health Research
Hobbs, Maurine R.
United States, Salt Lake City
The University of Utah
Granger, Donald L.
United States, Salt Lake City
The University of Utah
Weinberg, Joe Brice
United States, Durham
Duke University Medical Center
Peshu, Norbert M.
Kenya, Nairobi
Kenya Medical Research Institute
Mwaikambo, Esther D.
Tanzania, Dar es Salaam
Muhimbili Medical Centre
Marsh, Kevin
Kenya, Nairobi
Kenya Medical Research Institute
Roberts, David J.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Anstey, Nicholas M.
Australia, Darwin
Menzies School of Health Research
Statistics
Citations: 110
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1038/sj.gene.6363909
ISSN:
14664879
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study