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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study
Updates in Surgery, Volume 75, No. 3, Year 2023
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Description
The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135–15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359–5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138–5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184–5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598–9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090–6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286–5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912–7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138–0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143–0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990). Graphical abstract: [Figure not available: see fulltext.]. © 2023, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC10005914/bin/13304_2023_1488_MOESM1_ESM.doc
Authors & Co-Authors
Podda, Mauro Guido
Italy, Cagliari
Azienda Ospedaliero Universitaria Di Cagliari
Pellino, Gianluca
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Spain, Barcelona
Hospital Universitari Vall D'hebron
Di Saverio, S.
Italy, San Benedetto Del Tronto
“madonna Del Soccorso” General Hospital
Coccolini, Federico
Italy, Pisa
Azienda Ospedaliero Universitaria Pisana
Pacella, Daniela
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Cioffi, Stefano Piero Bernardo
Italy, Milan
Asst Grande Ospedale Metropolitano Niguarda
Virdis, Francesco
Italy, Milan
Asst Grande Ospedale Metropolitano Niguarda
Balla, Andrea
Italy, Milan
Ospedale San Paolo
Ielpo, Benedetto
Spain, Barcelona
Hospital Del Mar
Pata, Francesco
Unknown Affiliation
Poillucci, Gaetano
Italy, Rome
Azienda Ospedaliera Universitaria Policlinico Umberto I
Ortenzi, Monica
Italy, Ancona
Università Politecnica Delle Marche
Damaskos, Dimitrios
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
de Simone, Belinda D.
France, Poissy
Centre Hospitalier Intercommunal Poissy-st-germain-en-laye
Sartelli, Massimo
Italy, Macerata
Macerata Hospital
Leppäniemi, Ari Kalevi
Finland, Helsinki
Helsingin Yliopisto
Kumar, Jayant
United Kingdom, London
Imperial College London
Catena, Fausto
Italy, Cesena
Ospedale M. Bufalini
Di Martino, Marcello M.
Italy, Naples
Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli
Pisanu, Adolfo
Italy, Cagliari
Azienda Ospedaliero Universitaria Di Cagliari
Gerardi, C.
Unknown Affiliation
Gourgiotis, Stavros
Unknown Affiliation
Riboni, Cristiana
Unknown Affiliation
Giordano, Alessio Biagio Filippo
Unknown Affiliation
Ferrario, Luca
Unknown Affiliation
Vanni, Agnoletti
Unknown Affiliation
Mole, Damian J.
Unknown Affiliation
Agresta, Ferdinando
Unknown Affiliation
Prieto-Calvo, Mikel
Unknown Affiliation
Wilson, Michael S.J.
Unknown Affiliation
Soggiu, Fiammetta
Unknown Affiliation
Hamdan, Alaa
Unknown Affiliation
Gomes, Carlos Augusto
Unknown Affiliation
Fraga, Gustavo Pereira
Unknown Affiliation
Ioannidis, Argyrios
Unknown Affiliation
Demetrashvili, Zaza M.
Unknown Affiliation
Sahani, Saaz
Unknown Affiliation
Bains, Lovenish
Unknown Affiliation
Khamees, Almu'Atasim
Unknown Affiliation
Ababneh, Hazim S.
Unknown Affiliation
Aljaiuossi, Osama
Unknown Affiliation
Pimentel, Samuel
Unknown Affiliation
Mohamad, Ikhwan Sani
Unknown Affiliation
Yusoff, Ahmad Ramzi
Unknown Affiliation
Zãrnescu, Narcis Octavian
Unknown Affiliation
Calu, Valentin
Unknown Affiliation
Litvin, A. A.
Unknown Affiliation
Leško, Dušan
Unknown Affiliation
Elmehrath, Ahmed O.
Unknown Affiliation
Elshami, Mohamedraed
Unknown Affiliation
de Santibáñes, Martín
Unknown Affiliation
Gundara, Justin S.
Unknown Affiliation
Alawadhi, Kamel
Unknown Affiliation
Lui, Rashid N.S.
Unknown Affiliation
Julianov, Alexander E.
Unknown Affiliation
Ralon, Sergio
Unknown Affiliation
Garzali, Ibrahım Umar
Unknown Affiliation
Machain Vega, Gustavo Miguel
Unknown Affiliation
Quispe-Cruz, Darwin Artidoro
Unknown Affiliation
Orantia, Abigail Cheska C.
Unknown Affiliation
Walędziak, Maciej Stanisław
Unknown Affiliation
Ali, Syed Muhammad
Unknown Affiliation
Kovacevic, Bojan M.
Unknown Affiliation
Noel, Colin B.
Unknown Affiliation
Abdalah, Haidar M.
Unknown Affiliation
Kchaou, Ali
Unknown Affiliation
Isik, Arda A.
Unknown Affiliation
Ansaloni, Luca
Unknown Affiliation
Biffl, Walter L.
Unknown Affiliation
Guerrieri, Mario
Unknown Affiliation
Sartori, Alberto
Unknown Affiliation
Abradelo De Usera, Manuel
Unknown Affiliation
Nigri, Giuseppe R.
Unknown Affiliation
Di Lorenzo, Nicola
Unknown Affiliation
Mingoli, Andrea
Unknown Affiliation
Chiarugi, Massimo
Unknown Affiliation
Di Menno Stavron, Juliana
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Mazza, Óscar María
Unknown Affiliation
Valenzuela, J. I.
Unknown Affiliation
Alvarez, Fernando Andrés
Unknown Affiliation
Liaño, Julián Ezequiel
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Tefay, Joan S.
Unknown Affiliation
Alshaikh, Abdulrahman
Unknown Affiliation
Hasan, Layla
Unknown Affiliation
Calderan, Thiago Rodrigues Araújo
Unknown Affiliation
Hirano, Elcio Shiyoiti
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Dardanov, Dragomir
Unknown Affiliation
Saroglu, Azize S.
Unknown Affiliation
Atanasov, Boyko Tchavdarov
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Belev, Nikolay
Unknown Affiliation
Kovachev, Nikola
Unknown Affiliation
Chan, Shannon Melissa
Unknown Affiliation
Lok, Hon Ting
Unknown Affiliation
Salcedo, Diego Fernando
Unknown Affiliation
Robayo, Diana
Unknown Affiliation
Triviño, María Alejandra
Unknown Affiliation
Maňák, Jan
Unknown Affiliation
Awad, Ahmed K.
Unknown Affiliation
Elbadawy, Merihan A.
Unknown Affiliation
Nafea, Ahmed Mahmoud
Unknown Affiliation
Abdelsalam, Wafaa Mohamed
Unknown Affiliation
Emile, Sameh Hany
Unknown Affiliation
Elfallal, Ahmed Hossam
Unknown Affiliation
Elfeki, Hossam Ayman
Unknown Affiliation
Elghadban, Hosam M.
Unknown Affiliation
Shoma, Ashraf M.
Unknown Affiliation
Shetiwy, Mohamed Saad
Unknown Affiliation
Elbahnasawy, Mohamed
Unknown Affiliation
Mohamed, Shukri F.
Unknown Affiliation
Hamed, Emad F.
Unknown Affiliation
Khalil, Usama Ahmed
Unknown Affiliation
Chouillard, Élie K.
Unknown Affiliation
Gumbs, Andrew A.
Unknown Affiliation
Ioannidis, Orestis M.
Unknown Affiliation
Anestiadou, Elissavet
Unknown Affiliation
Manatakis, Dimitrios K.
Unknown Affiliation
Tasis, Nikolaos P.
Unknown Affiliation
Papadoliopoulou, Maria
Unknown Affiliation
Kapiris, Stylianos A.
Unknown Affiliation
Chouliaras, Christos
Unknown Affiliation
Mulita, Francesk
Unknown Affiliation
Theodorou, Dimitrios A.
Unknown Affiliation
Lostoridis, Eftychios
Unknown Affiliation
Nagorni, Eleni Aikaterini
Unknown Affiliation
Baili, Efstratia
Unknown Affiliation
Charalabopoulos, Alexandros
Unknown Affiliation
Liakakos, Theodore D.
Unknown Affiliation
Schizas, Dimitrios N.
Unknown Affiliation
MacHairas, Nikolaos A.
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Kalaitzakis, Evangelos
Unknown Affiliation
Lasithiotakis, Konstantinos G.
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Gupta, Amit K.
Unknown Affiliation
Magnoli, Matteo
Unknown Affiliation
Bottari, Andrea
Unknown Affiliation
Fortuna, Laura
Unknown Affiliation
Martellucci, Jacopo
Unknown Affiliation
Morino, Mario
Unknown Affiliation
Delogu, Daniele
Unknown Affiliation
Argenio, Giulio
Unknown Affiliation
Occhionorelli, Savino
Unknown Affiliation
Luppi, Davide
Unknown Affiliation
Pignata, Giusto
Unknown Affiliation
Andreuccetti, Jacopo
Unknown Affiliation
Fleres, Francesco
Unknown Affiliation
Clarizia, Guglielmo
Unknown Affiliation
Biloslavo, Alan
Unknown Affiliation
Mastronardi, Manuela
Unknown Affiliation
de Manzini, Nicolò
Unknown Affiliation
Marino, Marco V.
Unknown Affiliation
Anania, Gabriele
Unknown Affiliation
Bombardini, Cristina
Unknown Affiliation
Murzi, Valentina
Unknown Affiliation
Salvetti, Francesco
Unknown Affiliation
Viganò, Jacopo
Unknown Affiliation
Sganga, Gabriele
Unknown Affiliation
Bianchi, Valentina
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Fransvea, P.
Unknown Affiliation
Fontana, Tommaso
Unknown Affiliation
Papa, Mario V.
Unknown Affiliation
Jovine, E.
Unknown Affiliation
Mastrangelo, Laura
Unknown Affiliation
Ricci, Claudio
Unknown Affiliation
Aiolfi, Alberto
Unknown Affiliation
Cianci, Pasquale
Unknown Affiliation
Bini, Roberto
Unknown Affiliation
Chiara, Osvaldo O.
Unknown Affiliation
Marafante, C.
Unknown Affiliation
Pesce, Antonio
Unknown Affiliation
Fabbri, Nicolò
Unknown Affiliation
Frontali, A.
Unknown Affiliation
Favi, Francesco
Unknown Affiliation
Picariello, Erika
Unknown Affiliation
Rampini, Alessia
Unknown Affiliation
D’Acapito, Fabrizio
Unknown Affiliation
Solaini, Leonardo
Unknown Affiliation
Ferrara, Francesco
Unknown Affiliation
Picardi, Biagio
Unknown Affiliation
Galleano, R.
Unknown Affiliation
Perrone, Gennaro
Unknown Affiliation
Giuffrida, Mario C.
Unknown Affiliation
Butturini, Giovanni
Unknown Affiliation
Cicuttin, Enrico
Unknown Affiliation
Cremonini, Camilla
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Tartaglia, Dario
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Cillara, Nicola
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Lapolla, Pierfrancesco
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Brachini, Gioia
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Sammartano, Fabrizio F.
Unknown Affiliation
Rossi, S.
Unknown Affiliation
Puccioni, Caterina
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Lepiane, Pasquale
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Sasia, Diego
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Giraudo, Giorgio
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Caronna, Roberto
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Chirletti, Pietro
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Barone, Mirko
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Grande, Michele
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Siragusa, Leandro
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Di Carlo, Isidoro
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Veroux, Massimiliano
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Currò, Giuseppe
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Ammendola, Michele
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Tonini, Valeria
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Ceresoli, Marco
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Doria, Emanuele
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Visconti, Diego
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Awadi, Sajeda
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Bievel Radulescu, Raluca
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Gachabayov, Mahir
Unknown Affiliation
Abdullaev, Abakar Elbrusovich
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Panyko, Arpád
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Ausania, Fabio
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González-Abós, Carolina
Unknown Affiliation
Tejedor-Tejada, Javier
Unknown Affiliation
Mendoza-Moreno, Fernando
Unknown Affiliation
Matias-García, Belén
Unknown Affiliation
Sanchez-Guillen, Luís
Unknown Affiliation
Landaluce-Olavarria, Aitor
Unknown Affiliation
Estraviz-Mateos, Begoña
Unknown Affiliation
Alconchel, Felipe
Unknown Affiliation
Muñóz-Cruzado, Virginia Durán
Unknown Affiliation
Hamid, Hytham K.S.
Unknown Affiliation
Cristaudi, Alessandra
Unknown Affiliation
Tlili, Ahmed
Unknown Affiliation
Uzunoglu, Mustafa Yener
Unknown Affiliation
Azamat, Ibrahim Fethi
Unknown Affiliation
Omarov, Nail
Unknown Affiliation
Uymaz, Derya Salim
Unknown Affiliation
Altintoprak, Fatih
Unknown Affiliation
Akin, Emrah
Unknown Affiliation
Daş, Koray
Unknown Affiliation
Demirli Atlcl, Semra
Unknown Affiliation
Çolak, Elif F.
Unknown Affiliation
Altinel, Yuksel
Unknown Affiliation
Meric, Serhat
Unknown Affiliation
Aktimur, Yunus Emre
Unknown Affiliation
Khan, Mansoor Ali
Unknown Affiliation
Kotecha, Pinky
Unknown Affiliation
Ebied, Husam
Unknown Affiliation
Tebala, Giovanni Domenico
Unknown Affiliation
Chooklin, S. M.
Unknown Affiliation
Chuklin, Serhii S.
Unknown Affiliation
Statistics
Citations: 1
Authors: 242
Affiliations: 19
Identifiers
Doi:
10.1007/s13304-023-01488-6
ISSN:
2038131X
Research Areas
Food Security
Health System And Policy
Noncommunicable Diseases