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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, Uganda
Journal of Infectious Diseases, Volume 206, No. 2, Year 2012
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Description
Background.Human immunodeficiency virus (HIV) superinfection has been documented in high-risk individuals; however, the rate of superinfection among HIV-infected individuals within a general population remains unknown.Methods.A novel next-generation ultra-deep sequencing technique was utilized to determine the rate of HIV superinfection in a heterosexual population by examining two regions of the viral genome in longitudinal samples from recent HIV seroconverters (n = 149) in Rakai District, Uganda.Results.The rate of superinfection was 1.44 per 100 person years (PYs) (95% confidence interval [CI],. 4-2.5) and consisted of both inter-and intrasubtype superinfections. This was compared to primary HIV incidence in 20 220 initially HIV-negative individuals in the general population in Rakai (1.15 per 100 PYs; 95% CI, 1.1-1.2; P =. 26). Propensity score matching (PS) was used to control for differences in sociodemographic and behavioral characteristics between the HIV-positive individuals at risk for superinfection and the HIV-negative population at baseline and follow-up. After PS matching, the estimated rate of primary incidence was 3.28 per 100 PYs (95 CI, 2.0-5.3; P =. 07) controlling for baseline differences and 2.51 per 100 PYs (95 CI, 1.5-4.3; P =. 24) controlling for follow-up differences.Conclusions.This suggests that the rate of HIV superinfection in a general population is substantial, which could have a significant impact on future public health and HIV vaccine strategies. © 2012 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3415936/bin/supp_206_2_267__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3415936/bin/supp_jis325_jis325supp.pdf
Authors & Co-Authors
Redd, Andrew D.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Mullis, Caroline E.
United States, Baltimore
Johns Hopkins Medical Institutions
Serwadda, David Musoke
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
Makerere University
Kong, Xiangrong
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Martens, Craig A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Ricklefs, Stacy M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Tobian, Aaron A.R.
United States, Baltimore
Johns Hopkins Medical Institutions
Xiao, Changchang
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Grabowski, Mary Kate
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Nalugoda, Fred Kakaire
Uganda, Kalisizo
Rakai Health Sciences Program
Kigozi, Godfrey G.
Uganda, Kalisizo
Rakai Health Sciences Program
Laeyendecker, Oliver B.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Baltimore
Johns Hopkins Medical Institutions
Kagaayi, Joseph
Uganda, Kalisizo
Rakai Health Sciences Program
Sewankambo, Nelson K.
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
Makerere University
Gray, Ronald H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Porcella, Stephen F.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Wawer, Maria J.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Quinn, Thomas Charles
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Baltimore
Johns Hopkins Medical Institutions
Statistics
Citations: 72
Authors: 18
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/jis325
ISSN:
00221899
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Locations
Uganda