Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Protective effect of Moringa oleifera leaves against gentamicin-induced nephrotoxicity in rabbits
Experimental and Toxicologic Pathology, Volume 65, No. 3, Year 2013
Notification
URL copied to clipboard!
Description
Oxidative stress due to abnormal production of reactive oxygen species has been implicated in the nephrotoxicity induced by gentamicin. The nephroprotective effect of aqueous-ethanolic extract of Moringa oleifera leaves (150 and 300. mg/kg) was evaluated against gentamicin-induced (80. mg/kg) renal injury in rabbits. Serum urea and creatinine levels were evaluated as the markers of renal nephrotoxicity. At the end of the experiment, the kidneys of rabbits were excised for histological examinations and determination of lipid peroxidation levels. Serum urea and creatinine levels were reduced in the M. oleifera (150 and 300. mg/kg) plus gentamicin treated groups. On histological examinations, kidney of intoxicated rabbits groups which received M. oleifera extract showed reparative tendencies. A highly significant (. p<. 0.01) elevation was observed in lipid peroxidation (LPO) level in the kidneys of gentamicin-intoxicated rabbits whereas combined treatment of M. oleifera and gentamicin group showed a highly significant (. p<. 0.01) depletion in LPO. The present study indicates that aqueous-ethanolic extract of M. oleifera leaves attenuates renal injury in rabbits treated with gentamicin, possibly by inhibiting lipid peroxidation. © 2011 Elsevier GmbH.
Authors & Co-Authors
Ouedraogo, Moustapha
Burkina Faso, Ouagadougou
University of Ouagadougou
Belgium, Brussels
Université Libre de Bruxelles
Lamien-Sanou, Assita
Burkina Faso, Ouagadougou
University Hospital Yalgado Ouedraogo
Ramdé, Norbert W.
Burkina Faso, Ouagadougou
University Hospital Yalgado Ouedraogo
Ouédraogo, Aimé Sosthène
Burkina Faso, Ouagadougou
University Hospital Yalgado Ouedraogo
Ouedraogo, Maurice Sidnoma
Burkina Faso, Ouagadougou
University of Ouagadougou
Zongo, Salifou P.
Burkina Faso, Ouagadougou
University of Ouagadougou
Goumbri, Olga
Burkina Faso, Ouagadougou
University Hospital Yalgado Ouedraogo
Duez, Pierre
Belgium, Brussels
Université Libre de Bruxelles
Belgium, Mons
Université de Mons
Guissou, Pierre Innocent
Burkina Faso, Ouagadougou
University of Ouagadougou
Statistics
Citations: 93
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.etp.2011.11.006
ISSN:
09402993
e-ISSN:
16181433
Research Areas
Violence And Injury
Study Approach
Quantitative