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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prognostic performance of pretreatment systemic immune-inflammation index in women with epithelial ovarian cancer
Future Science OA, Volume 9, No. 10, Article FSO897, Year 2023
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Description
Purpose: This study investigated the prognostic performance of the systemic immune-inflammation index (SII) in patients with epithelial ovarian cancer (EOC) in Lagos, Nigeria. Methods: We performed a secondary analysis of the data of 91 women who had treatment for EOC between 2009 and 2018. The associations between pretreatment SII and survivals were tested. Results: Pretreatment SII more than 610.2 was a significant independent predictor of reduced progression-free survival (HR = 2.68; 95% CI, 1.17 to 6.09) while SII greater than 649.0 was a significant independent predictor of reduced 3-year overall survival (HR = 2.01; 95% CI, 1.01 to 3.99). Conclusion: These findings suggest that high SII may be a potential prognostic indicator and useful marker for more intensive surveillance and design of personalized treatment in patients with EOC. Plain language summary This study looked at how the systemic immune-inflammation index (SII) can predict the outcomes of patients with epithelial ovarian cancer (EOC). To do this, the data of 91 women who received treatment for EOC between 2009 and 2018 were analyzed. The study concluded that when the SII level was higher than 610.2 and 649.0, it was linked to a higher likelihood of EOC progressing sooner and of reduced survival at the 3-year mark, respectively. This suggests that a high SII might be a useful predictor to understand how EOC could progress and how well patients with EOC might survive. © 2023 The Authors.
Authors & Co-Authors
Okunade, Kehinde Sharafadeen
Nigeria, Lagos
University of Lagos
Nigeria, Lagos
Lagos University Teaching Hospital
John Olabode, Sarah Oluwatayo
Nigeria, Lagos
University of Lagos
Soibi-Harry, Adaiah Priscillia
Nigeria, Lagos
Lagos University Teaching Hospital
Okoro, Austin C.
Nigeria, Lagos
Lagos University Teaching Hospital
Adejimi, Adebola Afolake
Nigeria, Lagos
University of Lagos
Ademuyiwa, I. Y.
Nigeria, Lagos
University of Lagos
Osunwusi, Benedetto Oluwaseun
Nigeria, Lagos
Lagos University Teaching Hospital
Adelabu, Hameed
Nigeria, Lagos
University of Lagos
Salako, Omolola A.
Nigeria, Lagos
University of Lagos
Statistics
Citations: 2
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.2144/fsoa-2023-0108
ISSN:
20565623
Research Areas
Cancer
Study Locations
Nigeria
Participants Gender
Female