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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Oral lesions among HIV-infected children on antiretroviral treatment in West Africa
Tropical Medicine and International Health, Volume 19, No. 3, Year 2014
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Description
Objective: To estimate the prevalence of oral mucosal diseases and dental caries among HIV-infected children receiving antiretroviral treatment (ART) in West Africa and to identify the factors associated with the prevalence of oral mucosal lesions. Methods: Multicentre cross-sectional survey in five paediatric HIV clinics in Côte d'Ivoire, Mali and Sénégal. A standardised examination was performed by trained dentists on a random sample of HIV-infected children aged 5-15 years receiving ART. The prevalence of oral and dental lesions and mean number of decayed, missing/extracted and filled teeth (DMFdefT) in temporary and permanent dentition were estimated with their 95% confidence interval (95% CI). We used logistic regression to explore the association between children's characteristics and the prevalence of oral mucosal lesions, expressed as prevalence odds ratio (POR). Results: The median age of the 420 children (47% females) enrolled was 10.4 years [interquartile range (IQR) = 8.3-12.6]. The median duration on ART was 4.6 years (IQR = 2.6-6.2); 84 (20.0%) had CD4 count<350 cells/mm3. A total of 35 children (8.3%; 95% CI: 6.1-11.1) exhibited 42 oral mucosal lesions (24 were candidiasis); 86.0% (95% CI = 82.6-89.3) of children had DMFdefT ≥ 1. The presence of oral mucosal lesions was independently associated with CD4 count < 350 cells/mm3 (POR = 2.96, 95% CI = 1.06-4.36) and poor oral hygiene (POR = 2.69, 95% CI = 1.07-6.76). Conclusions: Oral mucosal lesions still occur in HIV-infected African children despite ART, but rarely. However, dental caries were common and severe in this population, reflecting the need to include oral health in the comprehensive care of HIV. © 2014 John Wiley & Sons Ltd.
Authors & Co-Authors
Meless, David Guanga
Cote D'ivoire, Abidjan
Fhb University
Ba, Boubacar
Mali, Bamako
Centre D'odonto-stomatologie
Faye, Malick L.
Senegal, Dakar
Hopital D'enfants Albert-royer Dakar
Diby, Jean Serge Elvis
Cote D'ivoire, Abidjan
Yopougon Attié Hospital
N'zore, Serge
Cote D'ivoire, Abidjan
Cctos
Datté, Sébastien Atta
Cote D'ivoire, Abidjan
Cctos
Diecket, Lucrèce
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
N'Diaye, Clémentine
Mali, Bamako
Hopital Gabriel Toure
Aka, Edmond Addi
Cote D'ivoire, Abidjan
Cepref-enfants
Kouakou, Kouadio P.
Cote D'ivoire, Abidjan
Cirba
Ba, Abou
Senegal, Dakar
Hopital D'enfants Albert-royer Dakar
Ékouévi, Didier Koumavi
France, Paris
Inserm
Dabis, Franćois Ç.Ois
France, Paris
Inserm
France, Bordeaux
Université de Bordeaux
Shiboski, Caroline H.
United States, San Francisco
University of California, San Francisco
Arrivé, Élise
France, Paris
Inserm
France, Bordeaux
Université de Bordeaux
Statistics
Citations: 33
Authors: 15
Affiliations: 12
Identifiers
Doi:
10.1111/tmi.12253
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Multi-countries
Ivory Coast
Mali
Participants Gender
Female