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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Synthesis of chalcones with anticancer activities
Molecules, Volume 17, No. 6, Year 2012
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Description
Several chalcones were synthesized and their in vitro cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3, human adenocarcinoma cell line HT-29 (colorectal cancer) and human normal liver cell line WRL-68 was evaluated. Most of the compounds being active cytotoxic agents, four of them with minimal IC 50 values were chosen and studied in detail with MCF-7 cells. The compounds 1, 5, 23, and 25 were capable in eliciting apoptosis in MCF-7 cells as shown by multiparameter cytotoxicity assay and caspase-3/7, -8, and -9 activities (p < 0.05). The ROS level showed 1.3-fold increase (p < 0.05) at the low concentrations used and thus it was concluded that the compounds increased the ROS level eventually leading to apoptosis in MCF-7 cells through intrinsic as well as extrinsic pathways. © 2012 by the authors.
Authors & Co-Authors
Syam, Suvitha
Malaysia, Serdang
Universiti Putra Malaysia
Abdelwahab, Siddig Ibarhim
Malaysia, Kuala Lumpur
Universiti Malaya
Al-Mamary, Mohammed Ali
Saudi Arabia, Al-baha
Al Baha University
Mohan, Syam Morali
Malaysia, Kuala Lumpur
Universiti Malaya
Statistics
Citations: 207
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.3390/molecules17066179
e-ISSN:
14203049
Research Areas
Cancer