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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Risk of metabolic syndrome and diabetes among young twins and singletons in Guinea-Bissau
Diabetes Care, Volume 36, No. 11, Year 2013
Notification
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Description
OBJECTIVE-Twins in Africa may be at increased risk of metabolic disorders due to strained conditions in utero, including high exposure to infections. We studied metabolic syndrome (MS) and diabetes mellitus (DM) among young twins and singletons in Guinea-Bissau. RESEARCH DESIGN AND METHODS-The study was cross-sectional and occurred from October 2009 until August 2011 at the Bandim Health Project, a demographic surveillance site in the capital Bissau. Twins and singleton controls between 5 and 32 years were visited at home. Fasting blood samples for metabolic measurements were collected. Zygosity was established genetically for a subset. DM was defined as HbA1c ≥6.5% (48 mmol/mol) and MS by the International Diabetes Federation criteria. RESULTS-HbA1c was available for 574 twins and 463 singletons. Mean age was 15.3 years versus 15.8 years, respectively. Eighteen percent of twins were monozygotic. There were no DM cases among twins but one among singletons. A total of 1.4% (8 of 574) of twins had elevated HbA1c (6.0-6.4%, 42-46 mmol/mol) compared with 2.4% (11 of 463) of singletons (P = 0.28). Mean HbA1c was 5.3% (34 mmol/mol) for both groups. MS data were available for 364 twins and 360 singletons. The MS prevalence was 3.0% (11 of 364) among twins and 3.6% (13 of 360) among singletons (P = 0.66). The prevalence of fasting blood glucose (F-glucose) ≥5.6 mmol/L was 34.9% (127 of 364) for twins versus 24.7% (89 of 360) for singletons (P = 0.003). Median homeostasis model assessment-insulin resistance did not differ (P = 0.34). CONCLUSIONS-The MS and DM prevalences among young individuals in Guinea-Bissau were low. Twins did not have a higher MS and DM burden than singletons, though elevated F-glucose was more common among twins. © 2013 by the American Diabetes Association.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3816924/bin/supp_36_11_3549__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3816924/bin/supp_dc12-2653v122653_DC122653SupplementaryData.pdf
Authors & Co-Authors
Bjerregaard-Andersen, Morten
Ghana, Accra
Indepth Network
Denmark, Odense
Odense Universitetshospital
Hansen, Lone
Denmark, Odense
Odense Universitetshospital
Da Silva, Leontina I.
Ghana, Accra
Indepth Network
Guinea-bissau
National Public Health Laboratory
Joaquím, Luis Carlos
Ghana, Accra
Indepth Network
Hennild, Ditte Egegaard
Ghana, Accra
Indepth Network
Denmark, Odense
Odense Universitetshospital
Christiansen, Lene
Denmark, Odense
Syddansk Universitet
Denmark, Odense
Odense Universitetshospital
Aaby, Peter
Ghana, Accra
Indepth Network
Denmark, Copenhagen
Statens Serum Institut
Denmark, Odense
Syddansk Universitet
Benn, Christine Stabell
Ghana, Accra
Indepth Network
Denmark, Copenhagen
Statens Serum Institut
Denmark, Odense
Syddansk Universitet
Christensen, Kaare
Denmark, Odense
Syddansk Universitet
Denmark, Odense
Odense Universitetshospital
Sodemann, Morten
Ghana, Accra
Indepth Network
Denmark, Odense
Odense Universitetshospital
Jensen, Dorte Møller
Denmark, Odense
Odense Universitetshospital
Beck-Nielsen, Henning
Denmark, Odense
Odense Universitetshospital
Statistics
Citations: 12
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.2337/dc12-2653
ISSN:
01495992
e-ISSN:
19355548
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Guinea
Guinea-Bissau