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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association between apolipoprotein E4 genotype and human immunodeficiency virusassociated dementia in younger adults starting antiretroviral therapy in South Africa
Journal of NeuroVirology, Volume 16, No. 5, Year 2010
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Description
It is not known whether the apolipoprotein E (ApoE) ε4 allelic variant is associated with human immunodeficiency virus (HIV)-associated dementia (HAD) in a South African population, where HIV clade C is predominant. ApoE genotyping was performed on 144 participants in a larger study of HIV-associated neurocognitive disorders (HAND). There was a lower frequency of the ε2 and ε3 alleles in the HIV-positive group, compared to a group of 300 community-based newborn infants. There were no differences in ApoE genotype across different categories of HAND. The ε4 allelic variant was less common in individuals with HAD than in those without HAD. These findings suggest that the ε4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa. © 2010 Journal of Neurovirology.
Authors & Co-Authors
Joska, John A.
South Africa, Cape Town
University of Cape Town
Combrinck, Marc Irwin
South Africa, Cape Town
University of Cape Town
Valcour, Victor G.
United States, San Francisco
University of California, San Francisco
United States, Honolulu
University of Hawaiʻi at Mānoa
Hoare, Jacqueline
South Africa, Cape Town
University of Cape Town
Leisegang, Felicity Margaret
South Africa, Cape Town
University of Cape Town
Mahne, Anna Cecilia
South Africa, Cape Town
University of Cape Town
Myer, Landon
South Africa, Cape Town
University of Cape Town
United States, New York
Mailman School of Public Health
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 39
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.3109/13550284.2010.513365
ISSN:
13550284
Research Areas
Genetics And Genomics
Infectious Diseases
Mental Health
Study Design
Cross Sectional Study
Study Locations
South Africa