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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Significantly skewed memory CD8
+
T cell subsets in HIV-1 infected infants during the first year of life
Clinical Immunology, Volume 130, No. 3, Year 2009
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Description
HIV-1 infection causes a severe T cell compromise; however, little is known about changes in naive, memory, effector and senescent T cell subsets during the first year of life. T cell subsets were studied over the first year of life in blood from 3 infant cohorts: untreated HIV-infected, HIV-exposed but uninfected, and HIV-unexposed. In HIV-infected infants, the frequency of CCR7+CD45RA+ naive CD8+ T cells was significantly decreased, while the frequency of CCR7-CD45RA- effector memory CD8+ T cells was increased, compared with the control cohorts. A larger population of CD8+ T cells in HIV-infected infants displayed a phenotype consistent with senescence. Differences in CD4+ T cell subset frequencies were less pronounced, and no significant differences were observed between exposed and unexposed HIV-uninfected infants. We concluded that the proportion of naive, memory, effector and senescent CD8+ T cells during the first year of life is significantly altered by HIV-1 infection. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Mansoor, Nazma
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Abel, Brian
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Scriba, Thomas J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hughes, Jane E.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
de Kock, Marwou
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Tameris, Michele D.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Mlenjeni, Silvia
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Denation, Lea
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Little, Francesca
South Africa, Cape Town
University of Cape Town
Gelderbloem, Sebastian J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hawkridge, Anthony J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Boom, W. Henry
United States, Cleveland
University Hospitals Case Medical Center
Kaplan, Gilla
United States, Newark
Public Health Research Institute
Hussey, Greg Dudley
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Statistics
Citations: 31
Authors: 15
Affiliations: 4
Identifiers
Doi:
10.1016/j.clim.2008.09.006
ISSN:
15216616
e-ISSN:
15217035
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study