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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Plasma virion reverse transcriptase activity and heat dissociation-boosted p24 assay for HIV load in Burkina Faso, West Africa
AIDS, Volume 19, No. 12, Year 2005
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Description
Background: In resource-limited settings, the requirement for inexpensive, easy-to-perform viral load monitoring has increased with greater antiretroviral drug availability. Objectives: To evaluate feasibility, in Burkina Faso, of a simple assay for plasma HIV reverse transcriptase (RT) activity quantification compared to heat dissociation-boosted (HDB) p24 antigen and RNA-based quantifications in plasma samples from HIV-infected patients. Methods: Plasma viraemia was quantified by RT activity, HDB-p24 and RNA copies in 84 samples from 70 HIV-1 group M-infected patients (82% non-B subtype, 93% treatment naive), including serial samples from nine patients. Results: RT activity detected 86% of plasma samples containing measurable RNA copies; corresponding to 0, 93 and 100% of samples with 1.7-4.0 log10, 4.1-4.8 log 10 and 4.9-6.7 log10 RNA copies/ml, respectively. HDB-p24 detected 77% of plasma samples containing measurable RNA copies; corresponding to 27, 80 and 86% of samples with 1.7-4.0 log10, 4.1-4.8 log 10 and 4.9-6.7 log10 RNA copies/ml, respectively. Measurement error based on one-way analysis of variance between RT activity and HDB-p24 values with RNA copies showed good agreement with RT activity (ME, <10%), however poorer agreement was obtained with HDB-p24 values (ME, >10%). Patient follow up showed a similar pattern of viraemia with RNA and RT activity assays. Conclusion: Field trials in Burkina Faso support the practical use of plasma RT activity assay as an affordable alternative for HIV viral load determination in regions where RNA detection remains difficult to perform. HDB-p24 use requires further evaluation before being considered as an alternative method in African HIV-infected patient follow up. © 2005 Lippincott Williams & Wilkins.
Authors & Co-Authors
Lombart, Jean Pierre
Burkina Faso, Ouagadougou
Chu Pédiatrique Charles-de-gaulle
Vray, Muriel M.
France, Paris
Institut Pasteur, Paris
Kafando, Anatole
Burkina Faso, Ouagadougou
Chu Pédiatrique Charles-de-gaulle
Lémée, Véronique
France, Rouen
Hopital Charles Nicolle
Ouédraogo-Traoré, Rasmata
Burkina Faso, Ouagadougou
Chu Pédiatrique Charles-de-gaulle
Corrigan, Gary E.
Sweden, Stockholm
Karolinska Institutet
Plantier, Jean Christophe
France, Rouen
Hopital Charles Nicolle
Simon, Franćois
France, Rouen
Hopital Charles Nicolle
Braun, Joséphine
France, Rouen
Hopital Charles Nicolle
Statistics
Citations: 19
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1097/01.aids.0000180098.58017.48
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Multi-countries
Burkina Faso