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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Novel adenoviruses in wild primates: A high level of genetic diversity and evidence of zoonotic transmissions
Journal of Virology, Volume 85, No. 20, Year 2011
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Description
Adenoviruses (AdVs) broadly infect vertebrate hosts, including a variety of nonhuman primates (NHPs). In the present study, we identified AdVs in NHPs living in their natural habitats, and through the combination of phylogenetic analyses and information on the habitats and epidemiological settings, we detected possible horizontal transmission events between NHPs and humans. Wild NHPs were analyzed with a pan-primate AdV-specific PCR using a degenerate nested primer set that targets the highly conserved adenovirus DNA polymerase gene. A plethora of novel AdV sequences were identified, representing at least 45 distinct AdVs. From the AdV-positive individuals, 29 nearly complete hexon genes were amplified and, based on phylogenetic analysis, tentatively allocated to all known human AdV species (Human adenovirus A to Human adenovirus G [HAdV-A to -G]) as well as to the only simian AdV species (Simian adenovirus A [SAdV-A]). Interestingly, five of the AdVs detected in great apes grouped into the HAdV-A, HAdV-D, HAdV-F, or SAdV-A clade. Furthermore, we report the first detection of AdVs in New World monkeys, clustering at the base of the primate AdV evolutionary tree. Most notably, six chimpanzee AdVs of species HAdV-A to HAdV-F revealed a remarkably close relationship to human AdVs, possibly indicating recent interspecies transmission events. © 2011, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3187507/bin/supp_85_20_10774__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3187507/bin/supp_85_20_10774__Table_S1_JVI00810_11.zip
Authors & Co-Authors
Wevers, Diana
Germany, Berlin
Robert Koch Institute
Metzger, Sonja
Germany, Berlin
Robert Koch Institute
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Babweteera, Fred
Uganda, Masindi
Budongo Conservation Field Station
Bieberbach, Marc
Germany, Berlin
Robert Koch Institute
Boesch, Christophe
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Cameron, Kenneth N.
Congo, Brazzaville
Wildlife Conservation Society
Couacy-Hymann, Emmanuel
United States, Davis
Mountain Gorilla Veterinary Project
Cranfield, Michael R.
United States, Davis
Mountain Gorilla Veterinary Project
Gray, Maryke
Rwanda, Kigali
International Gorilla Conservation Programme
Harris, Laurie A.
United States, Davis
School of Veterinary Medicine
Head, Josephine S.
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Jeffery, Kathryn J.
Gabon, Libreville
Agence Nationale Des Parcs Nationaux
Gabon
Institut de Recherche en é Cologie Tropicale
United Kingdom, Stirling
University of Stirling
Knauf, Sascha
Germany, Gottingen
Deutsches Primatenzentrum
Germany, Hannover
Fraunhofer Institute for Toxicology and Experimental Medicine Item
Lankester, Felix
United States, Chicago
Lincoln Park Zoo
Leendertz, Siv Aina Jensen
Germany, Berlin
Robert Koch Institute
Lonsdorf, Elizabeth V.
United States, Chicago
Lincoln Park Zoo
Mugisha, Lawrence
Uganda, Kampala
Makerere University
Nitsche, Andreas
Germany, Berlin
Robert Koch Institute
Reed, Patricia E.
Congo, Brazzaville
Wildlife Conservation Society
Robbins, Martha M.
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Travis, Dominic A.
United States, Saint Paul
College of Veterinary Medicine
Zommers, Zinta A.
United Kingdom, Oxford
University of Oxford
Leendertz, Fabian Hubertus
Germany, Berlin
Robert Koch Institute
Ehlers, Bernhard
Germany, Berlin
Robert Koch Institute
Statistics
Citations: 110
Authors: 24
Affiliations: 16
Identifiers
Doi:
10.1128/JVI.00810-11
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Genetics And Genomics
Infectious Diseases