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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Experimental heatstroke in baboon: Analysis of the systemic inflammatory response
Shock, Volume 24, No. 4, Year 2005
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Description
The objective of this study was to analyze the pattern of the inflammatory response to heatstroke in an experimental baboon model with a view to identifying potential target for therapeutic interventions. Blinded analysis of plasma collected from 12 juvenile baboons (Papio hamadryas) in heatstroke was used. Eight anesthetized animals were heat-stressed in an incubator at 44°C to 47°C until rectal temperature was 42.5°C (moderate heatstroke; n = 4) or systolic arterial pressure fell to <90 mmHg (severe heatstroke; n = 4) and were allowed to recover at room temperature. Four sham-heated animals served as a control group. We performed sequential measurement of cytokines. The rectal temperature on completion of heat stress was 42.5°C ± 0.0°C and 43.3°C ± 0.1°C in moderate and severe heatstroke, respectively. Heat stress elicited early, simultaneous release of anti-inflammatory cytokines and chemokines (IL-10, IL-1ra, sTNFr I and II, and IL-8). Circulating levels of IL-12p40 were significantly decreased, whereas TNFα, IL-1β, and IL-4 were below the detection limit in all animals. No baboon survived severe heatstroke; there was neurological morbidity without mortality in moderate heatstroke. Nonsurvivors displayed significantly greater activity/alterations in inflammation markers than survivors. Sham-heated animals had no evidence of inflammation activation. These results show that heatstroke activates complex systemic inflammatory and regulatory responses associated with outcome. Further definition of this ambivalent response is needed before identification of target of successful modulation may become possible. Copyright © 2005 by the Shock Society.
Authors & Co-Authors
Bouchama, A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Mohanna, Falah Hassan
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
El-Sayed, RA'Afat
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
ElDali, Abdelmoneim M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Saussereau, Elodie
France, Paris
Inserm
Chollet-Martin, Sylvie
France, Paris
Inserm
Ollivier, Véronique
France, Paris
Inserm
De Prost, Dominique
France, Paris
Inserm
France, Colombes
Hopital Louis-mourier
Roberts, George T.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 62
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1097/01.shk.0000180620.44435.9c
ISSN:
10732322
Study Design
Randomised Control Trial