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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Divergent trajectories of antiviral memory after SARS-CoV-2 infection
Nature Communications, Volume 13, No. 1, Article 1251, Year 2022
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Description
The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show a highly variable range of responses, some of which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B cell memory ELISpot) are stable. We use integrative analysis and a machine-learning approach (SIMON - Sequential Iterative Modeling OverNight) to explore this heterogeneity. We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory for longer term immunity associates with higher levels of neutralising antibodies against the infecting (Victoria) strain and also against variants B.1.1.7 (alpha) and B.1.351 (beta). These variable trajectories following early priming may define subsequent protection from severe disease from novel variants. © 2022, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8913789/bin/41467_2022_28898_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8913789/bin/41467_2022_28898_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8913789/bin/41467_2022_28898_MOESM3_ESM.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8913789/bin/41467_2022_28898_MOESM4_ESM.pdf
Authors & Co-Authors
Skelly, Dónal Thomas
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Ogbe, Ane T.
United Kingdom, Oxford
University of Oxford
Pace, Matthew J.
United Kingdom, Oxford
University of Oxford
Adland, Emily
United Kingdom, Oxford
University of Oxford
Alexander, Frances C.G.
United Kingdom, London
Uk Health Security Agency
Ali, Mohammad I.
United Kingdom, Oxford
University of Oxford
Ansari, M. Azim
United Kingdom, Oxford
University of Oxford
Belij-Rammerstorfer, Sandra
United Kingdom, Oxford
University of Oxford
Bibi, Sagida
United Kingdom, Oxford
University of Oxford
Blackwell, Luke
United Kingdom, Oxford
University of Oxford
Brown, Anthony
United Kingdom, Oxford
University of Oxford
Brown, Helen L.
United Kingdom, Oxford
University of Oxford
Clutterbuck, Elizabeth Ann
United Kingdom, Oxford
University of Oxford
de Silva, Thushan I.
United Kingdom, Sheffield
The University of Sheffield
Eyre, David William
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Lumley, Sheila F.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Flaxman, Amy L.
United Kingdom, Oxford
University of Oxford
Hackstein, Carl Philipp
United Kingdom, Oxford
University of Oxford
Harding, Adam C.
United Kingdom, Oxford
University of Oxford
Hill, Jennifer L.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Jay, Cecilia
United Kingdom, Oxford
University of Oxford
Johnson, Síle Ann
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Lie, Yolanda S.
United States, Burlington
Laboratory Corporation of America Holdings
Linder, Aline
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Longet, Stéphanie
United Kingdom, London
Uk Health Security Agency
United Kingdom, Oxford
University of Oxford
Marinou, Spyridoula
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Matthews, Philippa C.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Mellors, Jack
United Kingdom, London
Uk Health Security Agency
Petropoulos, Christos J.
United States, Burlington
Laboratory Corporation of America Holdings
Rongkard, Patpong
United Kingdom, Oxford
University of Oxford
Thailand, Bangkok
Mahidol Oxford Tropical Medicine Research Unit
Silva-Reyes, Laura
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Stockdale, Lisa K.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Taylor, Stephen Charles
United Kingdom, London
Uk Health Security Agency
Tipoe, Timothy
United Kingdom, Oxford
University of Oxford
Turtle, Lance C.W.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Liverpool Health Partners
Vieira, Vinicius A.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Wrin, Terri
United States, Burlington
Laboratory Corporation of America Holdings
Stafford, Lizzie
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Abuelgasim, Hibatullah
United Kingdom, Oxford
University of Oxford
Alhussni, Ahmed
United Kingdom, Oxford
University of Oxford
Cutteridge, Joseph
United Kingdom, Oxford
University of Oxford
Deeks, Alexandra S.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Denly, Lucy
United Kingdom, Oxford
University of Oxford
Dimitriadis, Stavros
United Kingdom, Oxford
University of Oxford
Holmes, Jennifer A.
United Kingdom, Oxford
University of Oxford
Kerneis, Sven A.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Lillie, Katy
United Kingdom, Oxford
University of Oxford
O’Donnell, Denise
United Kingdom, Oxford
University of Oxford
Ritter, Thomas G.
United Kingdom, Oxford
University of Oxford
Simmons, Beatrice
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Thomas, Sarah R.
United Kingdom, Oxford
University of Oxford
Watson, Adam J.R.
United Kingdom, Oxford
University of Oxford
Weeks, Esme
United Kingdom, Oxford
University of Oxford
Wilson, Robert
United Kingdom, Oxford
University of Oxford
Duncan, Christopher J.A.
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Moore, Shona C.
United Kingdom, Liverpool
University of Liverpool
Payne, Rebecca P.
United Kingdom, Newcastle
Newcastle University
Richter, Alex G.
United Kingdom, Birmingham
University of Birmingham
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Rowland-Jones, Sarah Louise
United Kingdom, Sheffield
Sheffield Teaching Hospitals Nhs Foundation Trust
United Kingdom, Sheffield
The University of Sheffield
Mentzer, Alexander J.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Cassar, Mark Philip
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Dong, Tao
United Kingdom, Oxford
University of Oxford
Fries, Anastasia
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Gilbert Jaramillo, Javier Andres
United Kingdom, Oxford
University of Oxford
Ho, Ling Pei
United Kingdom, Oxford
University of Oxford
Knight, Julian C.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Neubauer, Stefan
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Peng, Yanchun
United Kingdom, Oxford
University of Oxford
Petousi, Nayia
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Raman, Betty
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Talbot, Nick P.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Pollard, Andrew J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Lambe, Teresa
United Kingdom, Oxford
University of Oxford
Conlon, Christopher P.
United Kingdom, Oxford
University of Oxford
Jeffery, Katie J.M.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Travis, Simon P.L.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Frater, John
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Stafford, Lizzie
United Kingdom, Oxford
University of Oxford
Carroll, Miles W.
United Kingdom, London
Uk Health Security Agency
United Kingdom, Oxford
University of Oxford
James, William S.
United Kingdom, Oxford
University of Oxford
Klenerman, Paul
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Barnes, Eleanor J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Dold, Christina
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Dunachie, Susanna J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Thailand, Bangkok
Mahidol Oxford Tropical Medicine Research Unit
Statistics
Citations: 9
Authors: 85
Affiliations: 15
Identifiers
Doi:
10.1038/s41467-022-28898-1
ISSN:
20411723
Research Areas
Covid
Genetics And Genomics
Health System And Policy
Study Design
Cohort Study
Study Approach
Quantitative