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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antitubercular and phytochemical investigation of methanol extracts of medicinal plants used by the samburu community in Kenya
Tropical Journal of Pharmaceutical Research, Volume 9, No. 4, Year 2010
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Description
Purpose: To determine the potential benefits of nine medicinal plants used by the Samburu community for the treatment of tuberculosis. Methods: The extract was tested against four strains of Mycobacteria namely; Mycobacterium tuberculosis (Mtb), M. Kansasii (Mk), M. fortuitum (Mf), and M. smegmatis (Ms) using BACTEC MGIT 960 system. The crude extracts were also analyzed for the presence of phytochemical constituents. Results: Both the extracts of Scadoxus multiflorus and Acacia nilotica showed strong antimycobacterial activity against the four tuberculosis-causing strains. Eurphobia scarlatina was the most active against both the slow (Mtb and Mk) and the fast (Mf and Ms) growers with Zero GUs at 0.5mg/ml. Phytochemical screening indicated presence or absence of tannins, saponins and flavonoids, terpenoids, cardiac glycosides and alkaloids in the extracts. Conclusion: The data suggest that some of the methanol extracts could be a rich source of antituberculosis agents. The results further show that there is some merit in the use of some of the plants studied in alternative medical practice. Pharmacological and toxicological studies of the active plants are still under investigation. © Pharmacotherapy Group.
Authors & Co-Authors
Mariita, Richard M.
Kenya, Nairobi
Kenyatta University
Ogol, Callistus K.P.O.
Kenya, Nairobi
Kenyatta University
Oguge, Nicholas Otienoh
United States, Newtown
Earthwatch Institute
Okemo, Paul Owour
Kenya, Nairobi
Kenyatta University
Statistics
Citations: 58
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.4314/tjpr.v9i4.58935
ISSN:
15965996
e-ISSN:
15969827
Research Areas
Noncommunicable Diseases
Study Locations
Kenya