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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line
Bioorganic and Medicinal Chemistry Letters, Volume 19, No. 23, Year 2009
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Description
Synthesis of a new series of diarylureas and amides having pyrrolo[2,3-d]pyrimidine scaffold is described. Their in vitro antiproliferative activities against A375 human melanoma cell line and HS 27 fibroblast cell line were tested and the effect of substituents on pyrrolo[2,3-d]pyrimidine was investigated. The newly synthesized compounds, except N-acetyl derivatives (Id, Ie, and Im), generally showed superior or similar activity against A375 to Sorafenib. Among all of these derivatives, compounds Iq and Ir having imidazole and morpholine moieties, respectively, showed the most potent antiproliferative activity against A375. © 2009.
Authors & Co-Authors
Jung, Myung-ho
South Korea, Seoul
Korea Institute of Science and Technology
Choi, Won-kyoung
South Korea, Seoul
Korea Institute of Science and Technology
El-Gamal, Mohammed I.
South Korea, Seoul
Korea Institute of Science and Technology
South Korea, Daejeon
University of Science and Technology Ust
Park, Jin-hun
South Korea, Seoul
Korea Institute of Science and Technology
Yoo, Kyung-ho
South Korea, Seoul
Korea Institute of Science and Technology
Sim, Taebo
South Korea, Seoul
Korea Institute of Science and Technology
Lee, So-ha
South Korea, Seoul
Korea Institute of Science and Technology
Baek, Daejin
South Korea, Seosan
Hanseo University
Oh, Chang-hyun
South Korea, Seoul
Korea Institute of Science and Technology
South Korea, Daejeon
University of Science and Technology Ust
Statistics
Citations: 50
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.bmcl.2009.10.051
ISSN:
0960894X