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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
In vitro techniques to evaluate buccal films
Journal of Controlled Release, Volume 166, No. 1, Year 2013
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Description
Extensive research on transmucosal drug delivery in the past few decades has resulted in the clinical application of several drug molecules through the buccal route. Interestingly, most of the new chemical moieties under clinical trials are being screened for their potential to deliver through the buccal cavity. In this context, buccal film offers several advantages including convenient dosing and better patient compliance. However, the greatest challenge is to develop a high quality buccal film which also necessitates constant evaluation and understanding the performance of the dosage form, the critical steps to achieve a successful product development. Despite the intense focus on buccal film based drug delivery system, there are no official standardized methods for its evaluation. Significant efforts have been made to demonstrate and improve the efficacy, potency and safety of buccal film using in vitro, ex vivo and in vivo assessments. Besides the physical properties of the film, several other parameters such as residence time, mucoadhesion, drug release, in vitro and in vivo buccal permeation profiles and absorption kinetics of the drug are examined while characterizing the prepared buccal films. However, various research groups have employed different methods and experimental conditions to evaluate the formulation, which has limited the comparison of data between the research groups. This review provides an overview about the various parameters that are considered and assessed as a part of formulation development to ensure quality product with desired characteristics. © 2012 Elsevier B.V.
Authors & Co-Authors
Nair, Anroop B.
Saudi Arabia, Al-ahsa
King Faisal University
Kumria, Rachna
India, Ambala
Maharishi Markandeshwar Deemed to be University, Mullana
Sreeharsha, Nagaraja
Saudi Arabia, Al-ahsa
King Faisal University
Attimarad, Mahesh Veerabhadra
Saudi Arabia, Al-ahsa
King Faisal University
Aldhubiab, Bandar
Saudi Arabia, Al-ahsa
King Faisal University
Alhaider, Ibrahim Abdulrahman
Saudi Arabia, Al-ahsa
King Faisal University
Statistics
Citations: 232
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.jconrel.2012.11.019
ISSN:
01683659
e-ISSN:
18734995
Research Areas
Health System And Policy