Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Extensive HIV-1 intra-host recombination is common in tissues with abnormal histopathology
PLoS ONE, Volume 4, No. 3, Article e5065, Year 2009
Notification
URL copied to clipboard!
Description
There is evidence that immune-activated macrophages infected with the Human Immunodeficiency Virus (HIV) are associated with tissue damage and serve as a long-lived viral reservoir during therapy. In this study, we analyzed 780 HIV genetic sequences generated from 53 tissues displaying normal and abnormal histopathology. We found up to 50% of the sequences from abnormal lymphoid and macrophage rich non-lymphoid tissues were intra-host viral recombinants. The presence of extensive recombination, especially in non-lymphoid tissues, implies that HIV-1 infected macrophages may significantly contribute to the generation of elusive viral genotypes in vivo. Because recombination has been implicated in immune evasion, the acquisition of drug-resistance mutations, and alterations of viral co-receptor usage, any attempt towards the successful eradication of HIV-1 requires therapeutic approaches targeting tissue macrophages. © 2009 Lamers et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2659430/bin/pone.0005065.s001.doc
Authors & Co-Authors
Lamers, Susanna L.
United States, Thibodaux
Bioinfoexperts Llc
Salemi, Marco
United States, Thibodaux
Bioinfoexperts Llc
United States, Gainesville
University of Florida
Galligan, Derek C.
United States, San Francisco
Ucsf School of Medicine
De Oliveira, Tulio
United States, Thibodaux
Bioinfoexperts Llc
South Africa, Bellville
University of the Western Cape
Fogel, Gary B.
United States, San Diego
Natural Selection, Inc.
Granier, Sara C.
United States, Thibodaux
Bioinfoexperts Llc
Zhao, Li
China, Jinan
Shandong University
Brown, Joseph N.
United States, Gainesville
University of Florida
Morris, Alanna
United States, San Francisco
Ucsf School of Medicine
Masliah, Eliezer
United States, La Jolla
University of California, San Diego
McGrath, Michael S.
United States, San Francisco
Ucsf School of Medicine
United States, Burlingame
Pathologica Llc
United States, San Francisco
Aids and Cancer Specimen Resource
Statistics
Citations: 54
Authors: 11
Affiliations: 9
Identifiers
Doi:
10.1371/journal.pone.0005065
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases