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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Ovarian cysts and breast cancer: Results from the Women's Contraceptive and Reproductive Experiences Study
Breast Cancer Research and Treatment, Volume 109, No. 1, Year 2008
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Description
A diagnosis of ovarian cysts is likely an indicator of hormonal milieu and thus may be related to breast cancer risk. Recent studies have reported an inverse relationship between prior ovarian cyst diagnosis and breast cancer risk. We evaluated this relationship in the Women's Contraceptive and Reproductive Experiences (CARE) Study, a population-based case-control study conducted in Atlanta, Detroit, Philadelphia, Los Angeles, and Seattle. Cases had first primary invasive breast cancer diagnosed between 1994 and 1998 at ages 35-64 years. African American women were over-sampled. Controls were identified through random digit dialling and were frequency matched to cases on centre, race, and five-year age group. A total of 4575 cases and 4682 controls were interviewed. We used unconditional logistic regression adjusted for age and study centre within racial groups to estimate the odds ratio (OR) and 95% confidence interval (CI) for the relationship between prior ovarian cysts and breast cancer. Ovarian cyst diagnosis was associated with a significantly reduced risk among Caucasians (OR = 0.85, 95% CI 0.76-0.96) and among African Americans (OR = 0.68, 95% CI 0.57-0.81). The association in Caucasians was not significant within subgroups defined by menopausal status, hormone use, or gynecological surgery while the OR estimates in African Americans were consistently lower and frequently significant. These data are consistent with the previously reported inverse association between ovarian cysts and breast cancer, but the evidence for a relationship was stronger in African Americans than Caucasians. Additional studies are required to determine the specific cyst type(s) responsible for the observed relationship. © 2007 Springer Science+Business Media, LLC.
Authors & Co-Authors
Knight, Julia A.
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Lesosky, Maia R.
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Bernstein, Leslie R.
United States, Los Angeles
University of Southern California
Marchbanks, Polly A.X.
United States, Atlanta
Centers for Disease Control and Prevention
Daling, Janet R.
United States, Seattle
Fred Hutchinson Cancer Center
Whittemore, Alice S.
United States, Stanford
Stanford University School of Medicine
Statistics
Citations: 9
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1007/s10549-007-9634-4
ISSN:
01676806
Research Areas
Cancer
Health System And Policy
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Case-Control Study
Participants Gender
Female