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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Resveratrol reverses cadmium chloride-induced testicular damage and subfertility by downregulating p53 and Bax and upregulating gonadotropins and Bcl-2 gene expression
Journal of Reproduction and Development, Volume 60, No. 2, Year 2014
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Description
This study was performed to investigate the protective and therapeutic effects of resveratrol (RES) against CdCl2- induced toxicity in rat testes. Seven experimental groups of adult male rats were formulated as follows: A) controls+NS, B) control+vehicle (saline solution of hydroxypropyl cyclodextrin), C) RES treated, D) CdCl2+NS, E) CdCl2+vehicle, F) RES followed by CdCl2 and M) CdCl2 followed by RES. At the end of the protocol, serum levels of FSH, LH and testosterone were measured in all groups, and testicular levels of TBARS and superoxide dismutase (SOD) activity were measured. Epididymal semen analysis was performed, and testicular expression of Bcl-2, p53 and Bax was assessed by RT-PCR. Also, histopathological changes of the testes were examined microscopically. Administration of RES before or after cadmium chloride in rats improved semen parameters including count, motility, daily sperm production and morphology, increased serum concentrations of gonadotropins and testosterone, decreased testicular lipid peroxidation and increased SOD activity. RES not only attenuated cadmium chloride-induced testicular histopathology but was also able to protect against the onset of cadmium chloride testicular toxicity. Cadmium chloride downregulated the anti-apoptotic gene Bcl2 and upregulated the expression of pro-apoptotic genes p53 and Bax. Resveratrol protected against and partially reversed cadmium chloride testicular toxicity via upregulation of Bcl2 and downregulation of p53 and Bax gene expression. The antioxidant activity of RES protects against cadmium chloride testicular toxicity and partially reverses its effect via upregulation of BCl2 and downregulation of p53 and Bax expression. © 2014 by the Society for Reproduction and Development.
Authors & Co-Authors
Eleawa, Samy M.
Kuwait, Safat
College of Health Sciences
Al-Khateeb, Mahmoud Ahmad
Saudi Arabia, Abha
College of Medicine
Alhashem, Fahaid H.
Saudi Arabia, Abha
College of Medicine
Bin-Jaliah, Ismaeel
Saudi Arabia, Abha
College of Medicine
Sakr, Hussein F.
Saudi Arabia, Abha
College of Medicine
El-Refaey, Hesham M.
Saudi Arabia, Abha
King Khalid University
Elkarib, A. O.
Saudi Arabia, Abha
College of Medicine
Alessa, Riyad M.
Saudi Arabia, Abha
College of Medicine
Haidara, M. A.
Saudi Arabia, Abha
College of Medicine
Egypt, Giza
Cairo University
Shatoor, Abdullah Saleh
Saudi Arabia, Abha
College of Medicine
Khalil, Mohammad Adnan
Saudi Arabia, Riyadh
King Saud Bin Abdulaziz University for Health Sciences
Statistics
Citations: 100
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1262/jrd.2013-097
ISSN:
09168818
Research Areas
Genetics And Genomics
Participants Gender
Male