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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Drug resistance in plasma and breast milk after single-dose nevirapine in subtype C HIV type 1: Population and clonal sequence analysis
AIDS Research and Human Retroviruses, Volume 23, No. 8, Year 2007
Notification
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Description
Single-dose nevirapine (SD NVP) reduces intrapartum HIV-1 transmission, but nonnucleoside reverse transcription (NNRTI) resistance mutations can emerge. Population sequencing among 32 subtype C HIV-1-infected, SD NVP-exposed Zimbawean women demonstrated NNRTI resistance in 25/32 (78%) women: 23/30 (77%) at 2 weeks, 11/31 (35%) at 8 weeks, and 5/27 (19%) at 24 weeks. A total of 447 unique TA clones (median = 28 per time point), from four women with resistance at 8 weeks but wild-type virus by population sequence at 24 weeks, identified NNRTI mutations in a median of 76% (range: 55-96%) of individual clones at 2 weeks, 48% (range: 33-80%) at 8 weeks, and 5% (range: 0-15%) by 24 weeks. NNRTI mutations in breast milk clones at 2 and weeks from one woman varied significantly from plasma. Population sequencing underestimates the diversity of NNRTI resistance mutations within minority populations following SD NVP in subtype C HIV-1 viral RNA in plasma and breast milk. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Kassaye, Seble Getachew
United States, Palo Alto
Stanford University
Lee, Esther J.
United States, Palo Alto
Stanford University
Kantor, Rami
United States, Providence
Brown University
Johnston, Elizabeth R.
United States, Palo Alto
Stanford University
Winters, Mark A.
United States, Palo Alto
Stanford University
Zijenah, Lynn Sodai
Zimbabwe, Harare
University of Zimbabwe
Mateta, Patrick
Zimbabwe, Harare
University of Zimbabwe
Katzenstein, David A.
United States, Palo Alto
Stanford University
Statistics
Citations: 38
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1089/aid.2007.0045
ISSN:
08892229
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Participants Gender
Female