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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Progestogens to prevent preterm birth in twin pregnancies: An individual participant data meta-analysis of randomized trials
BMC Pregnancy and Childbirth, Volume 12, Article 13, Year 2012
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Description
Background: Preterm birth is the principal factor contributing to adverse outcomes in multiple pregnancies. Randomized controlled trials of progestogens to prevent preterm birth in twin pregnancies have shown no clear benefits. However, individual studies have not had sufficient power to evaluate potential benefits in women at particular high risk of early delivery (for example, women with a previous preterm birth or short cervix) or to determine adverse effects for rare outcomes such as intrauterine death.Methods/design: We propose an individual participant data meta-analysis of high quality randomized, double-blind, placebo-controlled trials of progestogen treatment in women with a twin pregnancy. The primary outcome will be adverse perinatal outcome (a composite measure of perinatal mortality and significant neonatal morbidity). Missing data will be imputed within each original study, before data of the individual studies are pooled. The effects of 17-hydroxyprogesterone caproate or vaginal progesterone treatment in women with twin pregnancies will be estimated by means of a random effects log-binomial model. Analyses will be adjusted for variables used in stratified randomization as appropriate. Pre-specified subgroup analysis will be performed to explore the effect of progestogen treatment in high-risk groups.Discussion: Combining individual patient data from different randomized trials has potential to provide valuable, clinically useful information regarding the benefits and potential harms of progestogens in women with twin pregnancy overall and in relevant subgroups. © 2012 Schuit et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Schuit, Ewoud
Netherlands, Utrecht
University Medical Center Utrecht
Stock, Sarah J.E.
United Kingdom, Edinburgh
Mrc Centre for Reproductive Health
Groenwold, Rolf H.H.
Netherlands, Utrecht
University Medical Center Utrecht
Maurel, Kimberly A.
United States, Fountain Valley
The Centre for Research, Education and Quality Creq
Combs, C. Andrew
United States, San Jose
Obstetrix Medical Group
Garite, Thomas J.
United States
The Centre for Research, Education and Quality Creq
Spong, Catherine Y.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Thom, Elizabeth A.
United States, Washington, D.c.
The George Washington University
Rouse, Dwight J.
United States, Providence
Brown University
United States
Providence Plantations
Caritis, Steve N.
United States, Pittsburgh
Upmc Magee-womens Hospital
Saade, George Robert
United States, Galveston
The University of Texas Medical Branch at Galveston
Zachary, Julia M.
United States, Washington, D.c.
The George Washington University
Norman, J. E.
Austria, Vienna
Medizinische Universität Wien
Rode, Line
Denmark, Copenhagen
Rigshospitalet
Klein, Katharina
Austria, Vienna
Medizinische Universität Wien
Tabor, Ann
Denmark, Copenhagen
Rigshospitalet
Çetingöz, Elçin
Turkey, Uskudar
Research Hospital
Morrison, John C.
United States, University
University of Mississippi
Magann, Everett F.
United States, Little Rock
University of Arkansas for Medical Sciences
Briery, Christian M.
United States, Shreveport
Willis Knighton Heart Institute
Serra, Vicente
Spain, Valencia
Universitat de València
Perales, Alfredo J.
Spain, Valencia
Hospital Universitari I Politècnic la fe
Meseguer, Juan
Spain, Murcia
Hospital Clínico Universitario Virgen de la Arrixaca
Nassar, Anwar H.
Lebanon, Beirut
American University of Beirut
Lim, Arianne C.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Moons, Karel G.M.
Netherlands, Utrecht
University Medical Center Utrecht
Kwee, Anneke B.
Netherlands, Utrecht
University Medical Center Utrecht
Mol, Ben Willem
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Statistics
Citations: 28
Authors: 28
Affiliations: 22
Identifiers
Doi:
10.1186/1471-2393-12-13
e-ISSN:
14712393
Research Areas
Disability
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Study Approach
Systematic review
Participants Gender
Female