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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Recognition and blocking of innate immunity cells by Candida albicans chitin
Infection and Immunity, Volume 79, No. 5, Year 2011
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Description
Chitin is a skeletal cell wall polysaccharide of the inner cell wall of fungal pathogens. As yet, little about its role during fungus-host immune cell interactions is known. We show here that ultrapurified chitin from Candida albicans cell walls did not stimulate cytokine production directly but blocked the recognition of C. albicans by human peripheral blood mononuclear cells (PBMCs) and murine macrophages, leading to significant reductions in cytokine production. Chitin did not affect the induction of cytokines stimulated by bacterial cells or lipopolysaccharide (LPS), indicating that blocking was not due to steric masking of specific receptors. Toll-like receptor 2 (TLR2), TLR4, and Mincle (the macrophage-inducible C-type lectin) were not required for interactions with chitin. Dectin-1 was required for immune blocking but did not bind chitin directly. Cytokine stimulation was significantly reduced upon stimulation of PBMCs with heat-killed chitin-deficient C. albicans cells but not with live cells. Therefore, chitin is normally not exposed to cells of the innate immune system but is capable of influencing immune recognition by blocking dectin-1-mediated engagement with fungal cell walls. © 2011, American Society for Microbiology.
Authors & Co-Authors
Mora-Montes, Héctor Manuel
United Kingdom, Aberdeen
University of Aberdeen
Mexico, Guanajuato
Universidad de Guanajuato
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Ferwerda, Gerben
Netherlands, Nijmegen
Radboud University Medical Center
Brown, Gordon D.A.
United Kingdom, Aberdeen
University of Aberdeen
Kullberg, Bart Jan
Netherlands, Nijmegen
Radboud University Medical Center
O'Callaghan, Christopher Anthony
United Kingdom, Oxford
University of Oxford
Odds, Frank C.
United Kingdom, Aberdeen
University of Aberdeen
Brown, Alistair J.P.
United Kingdom, Aberdeen
University of Aberdeen
Munro, Carol A.
United Kingdom, Aberdeen
University of Aberdeen
Gow, Neil A.R.
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 180
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1128/IAI.01282-10
ISSN:
10985522