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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer
Molecular and Cellular Endocrinology, Volume 301, No. 1-2, Year 2009
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Description
Steroid hormones and their metabolising enzymes have been studied extensively for their potential role in prostate cancer, with more recent interest in the androgen/estrogen inactivating enzyme 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4). Gene expression profiling showed HSD17B4 to be significantly overexpressed in prostate cancer compared to matched-benign epithelium. We therefore hypothesized that altered HSD17B4 expression may contribute to prostate cancer progression via altered hormone balance. In this study, HSD17B4 mRNA and protein expression were assessed by in situ hybridisation (ISH) and immunohistochemistry (IHC), respectively, in tissue arrays of prostate tissue from 172 patients treated by radical prostatectomy. Overexpression of HSD17B4 mRNA and protein was associated with prostate cancer (P < 0.0001) and multivariate Cox proportional hazards analysis, adjusted for known prognostic indicators, demonstrated HSD17B4 mRNA and high protein expression were significant independent predictors of poor patient outcome as measured by time until PSA relapse (mRNA: hazards ratio [HR] = 1.90, 95% confidence interval [CI] = 1.15-3.12; P < 0.0001; and protein: HR = 2.09, 95% CI = 1.31-3.33; P = 0.0026). Here we provide strong evidence that both mRNA and protein overexpression of HSD17B4 is not only associated with the presence of prostate cancer, but is also a significant independent predictor of poor patient outcome. © 2008 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Gardiner-Garden, Margaret
Australia, Sydney
Garvan Institute of Medical Research
Möller, Gabriele
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Kench, J. G.
Australia, Sydney
Garvan Institute of Medical Research
Australia, Sydney
Unsw Sydney
Australia, Sydney
Westmead Hospital
Stricker, Phillip D.
Australia, Sydney
St. Vincent's Hospital Sydney
Adamski, Jerzy
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Hayes, Vanessa M.
Australia, Sydney
Garvan Institute of Medical Research
Australia, Sydney
Unsw Sydney
Statistics
Citations: 40
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1016/j.mce.2008.11.021
ISSN:
03037207
Research Areas
Cancer
Genetics And Genomics
Health System And Policy