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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
No association between the DRD3 Ser9Gly polymorphism and schizophrenia
Schizophrenia Research, Volume 98, No. 1-3, Year 2008
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Description
Objective: To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia. Methods: 408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT). Results: No significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Ser), or G (Gly) were preferentially transmitted from parents to affected offspring. Conclusion: The hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported by this study. © 2007 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Fathalli, Ferid
Canada, Montreal
Le Centre de Recherche Douglas
Canada, Montreal
University of Montreal
Rouleau, Guy Armand
Canada, Montreal
University of Montreal
Canada, Montreal
Hôpital Notre-dame
Xiong, Lan
Canada, Montreal
Hôpital Notre-dame
Tabbane, Karim
Tunisia, Tunis
Université de Tunis
Benkelfat, Chawki
Canada, Montreal
Université Mcgill
de Guzman, Rosherrie
Canada, Montreal
Le Centre de Recherche Douglas
Danics, Zoltán
Hungary, Budapest
National Institute of Psychiatry and Neurology
Lal, Samarthji
Canada, Montreal
Le Centre de Recherche Douglas
Canada, Montreal
Université Mcgill
Sengupta, Sarojini M.
Canada, Montreal
Le Centre de Recherche Douglas
Joober, Ridha
Canada, Montreal
Le Centre de Recherche Douglas
Canada, Montreal
Université Mcgill
Statistics
Citations: 22
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.schres.2007.07.002
ISSN:
09209964
Research Areas
Genetics And Genomics
Mental Health