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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads
Journal of Infectious Diseases, Volume 195, No. 8, Year 2007
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Description
We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality (hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P = .003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Baeten, Jared M.
United States, Seattle
University of Washington
Chohan, Bhavna H.
United States, Seattle
University of Washington
Lavreys, Ludo
United States, Seattle
University of Washington
Kenya, Nairobi
University of Nairobi
Chohan, Vrasha
Kenya, Nairobi
University of Nairobi
McClelland, Raymond Scott
United States, Seattle
University of Washington
Kenya, Nairobi
University of Nairobi
Certain, Laura
United States, Seattle
University of Washington
Mandaliya, Kishor N.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Jaoko, Walter G.
Kenya, Nairobi
University of Nairobi
Overbaugh, Julie M.
United States, Seattle
Fred Hutchinson Cancer Research Center
Statistics
Citations: 268
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1086/512682
ISSN:
00221899
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Female