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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First-line antiretroviral therapy with efavirenz plus tenofovir disiproxil fumarate/emtricitabine or rilpivirine plus tenofovir disiproxil fumarate/emtricitabine: a durability comparison
HIV Medicine, Volume 19, No. 7, Year 2018
Notification
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Description
Objectives: The aim of this study was to compare the durabilities of efavirenz (EFV) and rilpivirine (RPV) in combination with tenofovir/emtricitabine (TDF/FTC) in first-line regimens. Methods: A multicentre prospective and observational study was carried out. We included all patients participating in the Italian Cohort Naive Antiretrovirals (ICONA) Foundation Study who started first-line combination antiretroviral therapy (cART) with TDF/FTC in combination with RPV or EFV, with a baseline viral load < 100 000 HIV-1 RNA copies/mL. Survival analyses using Kaplan–Meier (KM) curves and Cox regression with time-fixed covariates at baseline were employed. Results: Overall, 1490 ART-naïve patients were included in the study, of whom 704 were initiating their first cART with EFV and 786 with RPV. Patients treated with EFV, compared with those on RPV, were older [median 36 (interquartile range (IQR) 30–43) years vs. 33 (IQR 27–39) years, respectively; P < 0.001], were more frequently at Centers for Disease Control and Prevention (CDC) stage C (3.1% vs. 1.4%, respectively; P = 0.024), and had a lower median baseline CD4 count [340 (IQR 257–421) cells/μL vs. 447 (IQR 347–580) cells/μL, respectively; P < 0.001] and a higher median viral load [4.38 (IQR 3.92–4.74) log10 copies/mL vs. 4.23 (IQR 3.81–4.59) log10 copies/mL, respectively], (P = 0.004). A total of 343 patients discontinued at least one drug of those included in the first cART regimen, more often EFV (26%) than RPV (13%), by 2 years (P < 0.0001). After adjustment, patients treated with EFV were more likely to discontinue at least one drug for any cause [relative hazard (RH) 4.09; 95% confidence interval (CI) 2.89–5.80], for toxicity (RH 2.23; 95% CI 1.05–4.73) for intolerance (RH 5.17; 95% CI 2.66–10.07) and for proactive switch (RH 10.96; 95% CI 3.17–37.87) than those starting RPV. Conclusions: In our nonrandomized comparison, RPV was better tolerated, less toxic and showed longer durability than EFV, without a significant difference in rates of discontinuation because of failures. © 2018 British HIV Association
Authors & Co-Authors
Di Biagio, Antonio
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Maggiolo, Franco
Italy, Bergamo
Papa Giovanni Xxiii Hospital
Tavelli, Alessandro
Italy, Milan
Icona Foundation
Lo Caputo, Sergio
Italy, Bari
Azienda Ospedaliero-universitaria Consorziale Policlinico Di Bari
Bonora, Stefano
Italy, Turin
Università Degli Studi Di Torino
Zaccarelli, Mauro
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Caramello, Pietro
Italy, Turin
Ospedale Amedeo Di Savoia
Viscoli, Claudio
Italy, Genoa
Università Degli Studi Di Genova
D'Arminio Monforte, Antonella D.
Italy, Milan
Università Degli Studi Di Milano
Cozzi-Lepri, Alessandro
United Kingdom, London
University College London
Andreoni, Massimo G.
Unknown Affiliation
Angarano, Gioacchino
Unknown Affiliation
Antinori, Andrea
Unknown Affiliation
Castelli, Francesco
Unknown Affiliation
Cauda, Roberto
Unknown Affiliation
Di Perri, Giovanni
Unknown Affiliation
Galli, Massimo
Unknown Affiliation
Iardino, Rosaria
Unknown Affiliation
Ippolito, Giuseppe
Unknown Affiliation
Lazzarin, Adriano
Unknown Affiliation
Perno, Carlo Federico
Unknown Affiliation
Viale, Pierluigi
Unknown Affiliation
Castagna, Antonella
Unknown Affiliation
Ceccherini-Silberstein, Francesca
Unknown Affiliation
Girardi, Enrico
Unknown Affiliation
Mussini, Cristina
Unknown Affiliation
Puoti, Massimo
Unknown Affiliation
Balotta, Claudia
Unknown Affiliation
Bandera, Alessandra
Unknown Affiliation
Bonfanti, Paolo
Unknown Affiliation
Borderi, Marco
Unknown Affiliation
Calcagno, A.
Unknown Affiliation
Calza, Leonardo
Unknown Affiliation
Capobianchi, Maria Rosaria
Unknown Affiliation
Cingolani, A.
Unknown Affiliation
Cinque, P.
Unknown Affiliation
De Luca, Andrea
Unknown Affiliation
Gianotti, Nicola
Unknown Affiliation
Gori, Andrea
Unknown Affiliation
Guaraldi, Giovanni
Unknown Affiliation
Lapadula, Giuseppe
Unknown Affiliation
Lichtner, Miriam
Unknown Affiliation
Monno, Laura
Unknown Affiliation
Nozza, Silvia
Unknown Affiliation
Quiròs-Roldan, Eugenia
Unknown Affiliation
Rusconi, Stefano
Unknown Affiliation
Santoro, Maria Mercedes
Unknown Affiliation
Saracino, Annalisa L.
Unknown Affiliation
Fanti, Iuri
Unknown Affiliation
Galli, Luisa
Unknown Affiliation
Lorenzini, Patrizia
Unknown Affiliation
Rodano’, A.
Unknown Affiliation
Shanyinde, Milensu
Unknown Affiliation
Carrara, Stefania
Unknown Affiliation
Di Caro, Antonino
Unknown Affiliation
Quartu, Serena
Unknown Affiliation
Giacometti, Andrea R.
Unknown Affiliation
Verucchi, Gabriella
Unknown Affiliation
Quirino, Tiziana
Unknown Affiliation
Cacopardo, Bruno Santi
Unknown Affiliation
Celesia, Benedetto Maurizio
Unknown Affiliation
Segala, D.
Unknown Affiliation
Mastroianni, Claudio Maria
Unknown Affiliation
Castelli, Antonio P.
Unknown Affiliation
Rizzardini, Giuliano
Unknown Affiliation
Ridolfo, Anna Lisa
Unknown Affiliation
Carenzi, Laura
Unknown Affiliation
Tincati, Camilla
Unknown Affiliation
Chirianni, Antonio
Unknown Affiliation
Parruti, Giustino
Unknown Affiliation
Ursini, T.
Unknown Affiliation
Vullo, Vincenzo
Unknown Affiliation
Cristaudo, Antonio
Unknown Affiliation
Baldin, Gianmaria
Unknown Affiliation
Cicalini, Stefania
Unknown Affiliation
Nicastri, Emanuele
Unknown Affiliation
Acinapura, Rosa
Unknown Affiliation
Libertone, Raffaella
Unknown Affiliation
Latini, Alessandra
Unknown Affiliation
Rossetti, Barbara
Unknown Affiliation
Orofino, Giancarlo
Unknown Affiliation
Bassetti, Matteo
Unknown Affiliation
Pellizzer, Giampietro P.
Unknown Affiliation
Manfrin, Vinicio
Unknown Affiliation
Statistics
Citations: 14
Authors: 84
Affiliations: 11
Identifiers
Doi:
10.1111/hiv.12628
ISSN:
14642662
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study