Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Choroidal Thickness Profiles and Associated Factors in Myopic Children
Optometry and Vision Science, Volume 100, No. 1, Year 2023
Notification
URL copied to clipboard!
Description
SIGNIFICANCE This study addresses the lack of choroidal thickness (ChT) profile information available in European children and provides a baseline for further evaluation of longitudinal changes in ChT profiles in myopic children as a potential biomarker for myopia treatment and identifying children at risk of myopic progression. PURPOSE This study aimed to investigate ChT profiles and associated factors in myopic children. METHODS Baseline data of 250 myopic children aged 6 to 16 years in the Myopia Outcome Study of Atropine in Children clinical trial were analyzed. Choroidal thickness images were obtained using swept-source optical coherence tomography (DRI-OCT Triton Plus; Topcon Corporation, Tokyo, Japan). The macula was divided into nine Early Treatment of Diabetic Retinopathy Study locations with diameters of 1, 3, and 6 mm corresponding to the central fovea, parafoveal, and perifoveal regions. Multiple linear regression models were used to investigate determinants of ChT. RESULTS Choroidal thickness varied across the macular Early Treatment of Diabetic Retinopathy Study locations (P <.001): thickest in the perifoveal superior region (mean ± standard deviation, 249.0 ± 60.8 μm) and thinnest in the perifoveal nasal region (155.1 ± 50.3 μm). On average, ChT was greater in all parafoveal (231.8 ± 57.8 μm) compared with perifoveal (218.1 ± 49.1 μm) regions except superiorly where the ChT was greater in the perifoveal region. Longer axial length and higher myopic spherical equivalent refraction were consistently associated with thinner ChT at all locations in the multiple linear regression models. Asian race was significantly associated with thinner ChT only at parafoveal and perifoveal superior regions after Bonferroni correction (P=.004 and P=.001, respectively). CONCLUSIONS Choroidal thickness was thinnest in the nasal macular region and varied systematically across all macular locations, with axial length and spherical equivalent refraction being the strongest determinants of ChT. Longitudinal evidence will need to evaluate whether any differences in ChT profiles are predictive of myopic progression and to determine the role of ChT measurements in identifying myopic children most in need of myopia control treatment. © Lippincott Williams & Wilkins.
Authors & Co-Authors
Kobia-Acquah, Emmanuel
Ireland, Dublin
Technological University Dublin
Flitcroft, Daniel Ian
Ireland, Dublin
Technological University Dublin
Ireland, Dublin
Children's Health Ireland at Temple Street
Lingham, Gareth
Ireland, Dublin
Technological University Dublin
Paudel, Nabin
Ireland, Dublin
Technological University Dublin
Loughman, James J.
Ireland, Dublin
Technological University Dublin
Statistics
Citations: 2
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1097/OPX.0000000000001973
ISSN:
10405488
Research Areas
Maternal And Child Health
Study Design
Cohort Study