Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin
Steroids, Volume 87, Year 2014
Notification
URL copied to clipboard!
Description
Diosgenin has been modified to furostane derivatives after opening the F-spiroacetal ring. The aldehyde group at C26 in derivative 8 was unexpectedly transformed to the ketone 9. The structure of ketone 9 was confirmed by spectroscopy and finally by X-ray crystallography. Five of the diosgenin derivatives showed significant anticancer activity against human cancer cell lines. The most potent molecule of this series i.e. compound 7, inhibited cellular growth by arresting the population at G0/G1 phase of cell division cycle. Cells undergo apoptosis after exposure to the derivative 7 which was evident by increase in sub G0 population in cell cycle analysis. Docking experiments showed caspase-3 and caspase-9 as possible molecular targets for these compounds. This was further validated by cleavage of PARP, a caspase target in apoptotic pathway. Compound 7 was found non-toxic up to 1000 mg/kg dose in acute oral toxicity in Swiss albino mice. © 2014 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Hamid, Abdulmumeen A.
India, Lucknow
Central Institute of Medicinal and Aromatic Plants India
Nigeria, Ilorin
University of Ilorin
Hasanain, Mohammad
India, Lucknow
Central Drug Research Institute India
Singh, Arjun
India, Lucknow
Central Institute of Medicinal and Aromatic Plants India
Bhukya, Balakishan
India, Lucknow
Central Institute of Medicinal and Aromatic Plants India
Omprakash,
India, Lucknow
Central Institute of Medicinal and Aromatic Plants India
Vasudev, Prema G.
India, Lucknow
Central Institute of Medicinal and Aromatic Plants India
Sarkar, Jayanta
India, Lucknow
Central Drug Research Institute India
Chanda, Debabrata
India, Lucknow
Central Institute of Medicinal and Aromatic Plants India
Khan, Feroz
India, Lucknow
Central Institute of Medicinal and Aromatic Plants India
Aiyelaagbe, Olapeju O.
Nigeria, Ibadan
University of Ibadan
Negi, Arvind Singh
India, Lucknow
Central Institute of Medicinal and Aromatic Plants India
Statistics
Citations: 55
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1016/j.steroids.2014.05.025
ISSN:
0039128X
e-ISSN:
18785867
Research Areas
Cancer
Environmental
Health System And Policy
Study Design
Cross Sectional Study