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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Dissecting the relationship between plasma and tissue metabolome in a cohort of women with obesity: Analysis of subcutaneous and visceral adipose, muscle, and liver
FASEB Journal, Volume 36, No. 7, Article e22371, Year 2022
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Description
Untargeted metabolomics of blood samples has become widely applied to study metabolic alterations underpinning disease and to identify biomarkers. However, understanding the relevance of a blood metabolite marker can be challenging if it is unknown whether it reflects the concentration in relevant tissues. To explore this field, metabolomic and lipidomic profiles of plasma, four sites of adipose tissues (ATs) from peripheral or central depot, two sites of muscle tissue, and liver tissue from a group of nondiabetic women with obesity who were scheduled to undergo bariatric surgery (n = 21) or other upper GI surgery (n = 5), were measured by liquid chromatography coupled with mass spectrometry. Relationships between plasma and tissue profiles were examined using Pearson correlation analysis subject to Benjamini–Hochberg correction. Plasma metabolites and lipids showed the highest number of significantly positive correlations with their corresponding concentrations in liver tissue, including lipid species of ceramide, mono- and di-hexosylceramide, sphingomyelin, phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylethanolamine, dimethyl phosphatidylethanolamine, ether-linked PC, ether-linked PE, free fatty acid, cholesteryl ester, diacylglycerol and triacylglycerol, and polar metabolites linked to several metabolic functions and gut microbial metabolism. Plasma also showed significantly positive correlations with muscle for several phospholipid species and polar metabolites linked to metabolic functions and gut microbial metabolism, and with AT for several triacylglycerol species. In conclusion, plasma metabolomic and lipidomic profiles were reflective more of the liver profile than any of the muscle or AT sites examined in the present study. Our findings highlighted the importance of taking into consideration the metabolomic relationship of various tissues with plasma when postulating plasma metabolites marker to underlying mechanisms occurring in a specific tissue. © 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
Authors & Co-Authors
Kruger, Marlena Cathorina
New Zealand, Palmerston North
Massey University
New Zealand, Palmerston North
Riddet Institute
Cooper, Garth J.S.
New Zealand, Auckland
The University of Auckland
United Kingdom, Manchester
The University of Manchester
Sequeira, Ivana R.
New Zealand, Auckland
High-value Nutrition National Science Challenge
New Zealand, Auckland
The University of Auckland
Poppitt, Sally D.
New Zealand, Auckland
High-value Nutrition National Science Challenge
New Zealand, Palmerston North
Riddet Institute
New Zealand, Auckland
The University of Auckland
Fraser, Karl
New Zealand, Palmerston North
Agresearch Grasslands
New Zealand, Auckland
High-value Nutrition National Science Challenge
New Zealand, Palmerston North
Riddet Institute
Statistics
Citations: 1
Authors: 5
Affiliations: 7
Identifiers
Doi:
10.1096/fj.202101812R
ISSN:
08926638
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female