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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria
American Journal of Hematology, Volume 83, No. 6, Year 2008
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Description
Pulmonary artery systolic hypertension is common and associated with increased mortality among adult sickle cell disease (SCD) patients in the United States. Although the prevalence of SCD is highest in sub-Saharan Africa, the frequency of pulmonary artery systolic hypertension and the risk factors for the development of pulmonary hypertension have not been reported from Africa. We studied 208 hydroxyurea naïve Nigerian SCD patients at steady state and 94 healthy controls. Pulmonary artery systolic hypertension was defined prospectively as tricuspid regurgitant jet velocity ≥2.5 m/sec. Results were compared with a previously published US prospective SCD cohort. Only 7% of Nigerians compared with 46% of US adults with SCD were >35 years. Tricuspid regurgitant jet velocity was ≥2.5 m/sec in 25% of Nigerian SCD patients. Higher jet velocity was associated with greater serum globulin (P = 0.002), blood urea nitrogen (P = 0.019) and lactate dehydrogenase concentrations (P = 0.026) and with inability to walk >300 m in 6 min (P = 0.042). Compared with the US cohort, Nigerian patients had more hemolysis as indicated by lower hemoglobin and higher lactate dehydrogenase concentrations (P ≤ 0.003). Pulmonary hypertension is common among Nigerian SCD patients. The public health implication of this finding is significant considering the potential number of individuals at risk for this complication. Better understanding of the long term outcome of pulmonary hypertension and causes of death in SCD and the institution of preventive measures are major public health challenges for Africa. The inclusion of African sites in sickle cell pulmonary hypertension clinical trials should be encouraged. © 2008 Wiley-Liss, Inc.
Authors & Co-Authors
Aliyu, Zakari Yusufu
United States, Washington, D.c.
The Center for Sickle Cell Disease
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
United States, Washington, D.c.
Howard University
Gordeuk, Victor R.
United States, Washington, D.c.
The Center for Sickle Cell Disease
Sachdev, Vandana
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Babadoko, Ahmadu Aliyu
Nigeria, Zaria
Ahmadu Bello University
Mamman, Aisha Indo
Nigeria, Zaria
Ahmadu Bello University
Akpanpe, Peter
Nigeria, Zaria
Ahmadu Bello University
Attah, Ester
Nigeria, Zaria
Ahmadu Bello University
Suleiman, Yusuf
Nigeria, Zaria
Ahmadu Bello University
Yusuf, Jamilu Abdullahi
Nigeria, Zaria
Ahmadu Bello University
Mendelsohn, Laurel
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Kato, Gregory J.
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Gladwin, Mark T.
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Statistics
Citations: 104
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1002/ajh.21162
ISSN:
03618609
e-ISSN:
10968652
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Nigeria