Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis
Atherosclerosis, Volume 216, No. 1, Year 2011
Notification
URL copied to clipboard!
Description
Objective: To assess the influence of the TNFA rs1800629 (G > A) polymorphism in the risk of cardiovascular (CV) disease and subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Methods: 587 patients fulfilling the 1987 American College of Rheumatology classification criteria for RA were studied. Patients were genotyped for the TNFA rs1800629 polymorphism using predesigned TaqMan single nucleotide polymorphism genotyping assay. Also, HLA-DRB1 genotyping was performed using molecular based methods. Carotid artery intima-media thickness, flow-mediated endothelium-dependent and endothelium independent vasodilatation, used as surrogate markers of subclinical atherosclerosis, were measured in a subgroup of patients. Results: We observed a higher frequency of carriers of the minor allele A among the patients with CV disease (with 37.6% vs. without 27.9%, p= 0.06, OR 1.56 [95% confidence interval-CI 0.95-2.54]). Carriers of the minor allele A exhibited a higher risk of CV events after adjustment for demographic and traditional CV risk factors (p= 0.023, HR 1.72 [95% CI 1.076-2.74]). Also, a significant interaction between this polymorphism and the presence of the rheumatoid shared epitope (SE) was observed (p= 0.024). Due to this, the association between carriers of the minor allele A and CV disease was only present in carriers of the SE, even after adjustment (p= 0.001, HR 2.43 [95% CI 1.41-4.19]). No significant association between the TNFA variant and the surrogate markers of subclinical atherosclerosis was observed. Conclusion: Our results show that TNFA rs1800629 gene polymorphism is associated with predisposition to CV complications in patients with RA. This predisposition is restricted to individuals carrying the rheumatoid SE. © 2011 Elsevier Ireland Ltd.
Authors & Co-Authors
Rodríguez-Rodríguez, Luís Pablo
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Spain, Madrid
Hospital Clínico San Carlos
González-Juanatey, Carlos
Spain, Lugo
Complejo Hospitalario Xeral Calde
Palomino-Morales, Rogelio Jesús
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Vázquez-Rodríguez, Tomás Ramón
Spain, Lugo
Complejo Hospitalario Xeral Calde
Miranda-Filloy, José Alberto
Spain, Lugo
Complejo Hospitalario Xeral Calde
Fernàndez-Gutiérrez, Benjamín
Spain, Madrid
Hospital Clínico San Carlos
Llorca-Díaz, Javier Francisco
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Statistics
Citations: 127
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.atherosclerosis.2010.10.052
ISSN:
00219150
Research Areas
Genetics And Genomics
Noncommunicable Diseases