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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan
Malaria Journal, Volume 10, Article 258, Year 2011
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Description
Background: Placental malaria and pre-eclampsia occur frequently in women in tropics and are leading causes of maternal and perinatal morbidities and mortality. Few data exist concerning the interaction between placental malaria and pre-eclampsia. Methods. A case control study was conducted in Medani Hospital, which locates in an area of unstable malaria transmission in Central Sudan. Case (N = 143) were women with pre-eclampsia, which was defined as systolic blood presure140 mm Hg or diastolic blood pressure 90 mm Hg and proteinuria. Controls were parturient women (N = 143) without any blood pressure values > 139/89 mm Hg or proteinuria. Obstetrical and medical characteristics were gathered from both groups through structured questionnaires. Placental histopathology examinations for malaria were performed. Results: Twenty-eight (19.6%) vs. 16 (11.2%); P = 0.04 of the cases vs. controls, had placental malaria infections. Five (2%), 1 (2%) and 22 (28.0%) vs. 1, 2 and 13 of the placentae showed acute, chronic and past infection on histopathology examination in the two groups respectively, while 115 (80.4%) vs.127 (88.8%) of them showed no infection, P = 0.04. In multivariate analysis, while there were no associations between age, parity, educational level, lack of antenatal care, blood groups and body mass index and pre-eclampsia; family history of hypertension and placental malaria (OR = 2.3, 95% CI = 1.0-5.2; P = 0.04) were significantly associated with pre-eclampsia. Conclusion: Placental malaria was associated with pre-eclampsia. Further research is needed. © 2011 Adam et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Adam, Ishag I.
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Elhassan, M. Elhassan
Sudan, Wad Medani
University of Gezira
Mohmmed, Ahmed A.
Sudan, Khartoum
National Ribat University
Salih, Magdi Mansour Abdel Farage
Sudan, Khartoum
Khartoum University
Elbashir, Mustafa Idris
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Statistics
Citations: 45
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1186/1475-2875-10-258
e-ISSN:
14752875
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Case-Control Study
Study Locations
Sudan
Participants Gender
Female