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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Factors influencing health related quality of life in cancer patients with bone metastases
Journal of Palliative Medicine, Volume 16, No. 8, Year 2013
Notification
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Description
Objective: Health related quality of life (HRQOL) is a multidimensional concept that is especially important for cancer patients with bone metastases, as maintaining and improving HRQOL is often the main focus of treatment. This study aims to determine factors that may influence HRQOL, which may in turn influence treatment and care of patients. Methods: Patients (n=396) completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) Bone Metastases module (BM22) at baseline. The EORTC QLQ-BM22 consists of four scales: painful site (PS), pain characteristics (PC), functional interference (FI), and psychosocial aspect (PA) scales. EORTC QLQ-BM22 data, together with sociodemographic and medical factors were analyzed by univariate analysis of variance (ANOVA). Items of significance were determined through backward selection, which were then put through multivariate analysis to determine further significance. Results: Through ANOVA analysis, KPS>80 and breast primary histology were predictive of better HRQOL in the PS scale, while KPS>80, female gender, and breast primary histology were predictive of better HRQOL in the PC and FI scales. KPS>80 and prostate primary histology were predictive of better HRQOL in the PA scale. KPS>80 and primary cancer site were confirmed as significant predictive factors in multivariate analysis. Recommendations: This study identified baseline factors of gender, performance status, and primary histology as determinants of HRQOL in patients with bone metastases. Further study focusing on current treatment (chemotherapy, bisphosphonates, and radiotherapy) and spiritual well-being may identify additional factors affecting HRQOL. Understanding the influence of these factors will allow health care professionals to provide more effective palliative care. © 2013, Mary Ann Liebert, Inc.
Authors & Co-Authors
Wong, Erin T.
Canada, Toronto
University of Toronto
Chow, Edwardedward L.W.
Canada, Toronto
University of Toronto
Zhang, Liying
Canada, Toronto
University of Toronto
Bedard, Gillian
Canada, Toronto
University of Toronto
Lam, Kinsey
Canada, Toronto
University of Toronto
Fairchild, Alysa M.
Canada, Edmonton
Cross Cancer Institute
Vassiliou, Vassilios P.
Cyprus, Nicosia
Bank of Cyprus Group Oncology Centre
Alm el-Din, Mohamed A.
Egypt, Tanta
Tanta University Hospitals
Jesus-Garcia, Reynaldo
Brazil, Sao Paulo
Universidade Federal de São Paulo
Kumar, Aswin
India, Thiruvananthapuram
Regional Cancer Center
Forges, Fabien
France, Saint-etienne
Lucien Neuwirth Cancer Institute
Tseng, Lingming
Taiwan, Taipei
National Yang-ming University Taiwan
Hou, Mingfeng
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Chie, Wei-Chu
Taiwan, Taipei
National Taiwan University
Bottomley, Andrew
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Statistics
Citations: 17
Authors: 15
Affiliations: 11
Identifiers
Doi:
10.1089/jpm.2012.0623
ISSN:
10966218
Research Areas
Cancer
Disability
Participants Gender
Female