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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Differential cytotoxicity and sonosensitization by sanazole: Effect of cell type and acoustic parameters
Journal of Medical Ultrasonics, Volume 38, No. 2, Year 2011
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Description
Purpose: Although sanazole has been used as a hypoxic radiosensitizer, we recently reported on its ability to sensitize U937 cells to hyperthermia and X-irradiation under aerobic conditions, enhancing apoptotic cell death following the combined treatment. The current study was undertaken to evaluate the effect of sanazole as a sonosensitizer under previously studied acoustic conditions of different pulse repetition frequencies, using two cell lines representative of solid tumours and haematopoietic cancers. Methods: Cells were treated with different doses of sanazole. Flow-cytometric analysis and DNA fragmentation assay were carried out at different times, and morphological features were also inspected. For ultrasound treatment, cells were pre-incubated with a non-cytotoxic dose of sanazole for 30 min before exposure. Evaluation of cell killing and a parallel examination of intracellular oxidative stress levels in both cell lines were performed using flow cytometry. Results: Sanazole alone displayed selective cytotoxic effects towards solid tumour-derived cancer cells, resulting in complete cell death after 24 h of treatment, and enhanced the ultrasound-induced cell killing 6 h post-treatment. The enhancement seemed to be mediated by an additive increase in intracellular oxidative stress levels. Conclusion: Sanazole seems to be an efficient cytotoxic agent for the treatment of solid tumours and a promising sonosensitizer under aerobic conditions. © 2010 The Japan Society of Ultrasonics in Medicine.
Authors & Co-Authors
Hassan, Mariame Ali
Japan, Toyama
University of Toyama
Egypt, Cairo
Faculty of Pharmacy
Furusawa, Yukihiro
Japan, Toyama
University of Toyama
Zhao, Qing Li
Japan, Toyama
University of Toyama
Takasaki, Ichiro
Japan, Toyama
University of Toyama
Feril, Loreto B.
Japan, Fukuoka
Fukuoka University
Tachibana, Katsuro
Japan, Fukuoka
Fukuoka University
Kudo, Nobuki
Japan, Sapporo
Hokkaido University
Minemura, Masami
Japan, Toyama
University of Toyama
Sugiyama, Toshiro
Japan, Toyama
University of Toyama
Kondo, Takashi
Japan, Toyama
University of Toyama
Statistics
Citations: 10
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1007/s10396-010-0295-2
ISSN:
13464523
e-ISSN:
16132254
Research Areas
Cancer
Genetics And Genomics
Health System And Policy