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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Endothelial nitric oxide synthase (G894T) gene polymorphism in a random sample of the Egyptian population: Comparison with myocardial infarction patients
Genetic Testing and Molecular Biomarkers, Volume 16, No. 7, Year 2012
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Description
Aim: The aim of this study was to detect endothelial nitric oxide synthase (eNOS) Glu298Asp gene variants in a random sample of the Egyptian population, compare it with those from other populations, and attempt to correlate these variants with serum levels of nitric oxide (NO). The association of eNOS genotypes or serum NO levels with the incidence of acute myocardial infarction (AMI) was also examined. Methods: One hundred one unrelated healthy subjects and 104 unrelated AMI patients were recruited randomly from the 57357 Hospital and intensive care units of El Demerdash Hospital and National Heart Institute, Cairo, Egypt. eNOS genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. Serum NO was determined spectrophotometrically. Results: The genotype distribution of eNOS Glu298Asp polymorphism determined for our sample was 58.42% GG (wild type), 33.66% GT, and 7.92% TT genotypes while allele frequencies were 75.25% and 24.75% for G and T alleles, respectively. No significant association between serum NO and specific eNOS genotype could be detected. No significant correlation between eNOS genotype distribution or allele frequencies and the incidence of AMI was observed. Conclusion: The present study demonstrated the predominance of the homozygous genotype GG over the heterozygous GT and homozygous TT in random samples of Egyptian population. It also showed the lack of association between eNOS genotypes and mean serum levels of NO, as well as the incidence of AMI. © Copyright 2012, Mary Ann Liebert, Inc.
Authors & Co-Authors
Gad, Mohamed Zakaria
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Abdel Rahman, Mohamed F.
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Hashad, Ingy M.
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Abdel-Maksoud, Sahar M.
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Farag, Nabil Mahmoud
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Abou-Aisha, Khaled
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Statistics
Citations: 22
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1089/gtmb.2011.0342
ISSN:
19450265
e-ISSN:
19450257
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Egypt