Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
AhR and PPARα: Antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11
Xenobiotica, Volume 35, No. 1, Year 2005
Notification
URL copied to clipboard!
Description
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates a spectrum of toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. The peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor super-family of ligand-activated transcription factors and it functions as an obligate heterodimer with retinoid X-receptor alpha RXRa. The aim was to investigate whether the negative cross-talk recently proposed by the present authors between AhR and PPARα on CYP4A and CYP1A has any impact on other cytochrome P450 enzymes. Treatment of male Wistar rats with a PPARα ligand clofibric acid (CA) induced CYP2B1/2 and CYP3A proteins, activities, and the mRNA expression of CYP2B1, CYP2B2, CYP3A1 and CYP3A2, and suppressed CYP2C11 protein, activities and mRNA expression. AhR ligand Sudan III (S.III) treatment decreased basal and CA-induced CYP2B, CYP3A and CYP2C11 protein, activities and mRNA expression. To the best of the authors' knowledge, this is the first study showing the presence of mutual effects of AhR and PPARα on CYP2B and CYP3A and an additive inhibitory effect on CYP2C11 in the livers of male rats. © 2005 Taylor & Francis Ltd.
Authors & Co-Authors
Ibrahim, Zein Shabaan
Japan, Sapporo
Graduate School of Veterinary Medicine
Soliman, Mohamed Mohamed
Japan, Sapporo
Graduate School of Veterinary Medicine
El-Shazly, Samir Ahmed M.
Egypt, Tanta
Tanta University
Elbohi, Khlood M.
Japan, Sapporo
Graduate School of Veterinary Medicine
Abdelazeez, A.
Egypt, Tanta
Tanta University
Kehelo, K.
Egypt, Tanta
Tanta University
Kim, H. S.
Japan, Sapporo
Graduate School of Veterinary Medicine
Muzandu, Kaampwe
Japan, Sapporo
Graduate School of Veterinary Medicine
Ishizuka, Mayumi
Japan, Sapporo
Graduate School of Veterinary Medicine
Kazusaka, Akio
Japan, Sapporo
Graduate School of Veterinary Medicine
Fujita, Shoichi
Japan, Sapporo
Graduate School of Veterinary Medicine
Statistics
Citations: 43
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1080/00498250400021804
ISSN:
00498254
Research Areas
Cancer
Environmental
Study Locations
Sudan
Participants Gender
Male