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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study
Leukemia Research, Volume 34, No. 9, Year 2010
Notification
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Description
The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naïve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd.
Authors & Co-Authors
Gattermann, Norbert
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Finelli, Carlo
Italy, Bologna
Irccs Azienda Ospedaliero-universitaria Di Bologna
Della Porta, Matteo
Italy, Pavia
Università Degli Studi Di Pavia, Facoltà Di Medicina e Chirurgia
Fénaux, Pierre
France, Bobigny
Hopital Avicenne
Ganser, Arnold
Germany, Hannover
Hannover Medical School
Guerci-Bresler, Agnès
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Schmid, Mathias
Germany, Ulm
Universitätsklinikum Ulm
Taylor, Kerry
Australia, Brisbane
Mater Hospital Brisbane
Vassilieff, Dominique
France, Paris
Hopital Cochin Ap-hp
Habr, Dany
Switzerland, Basel
Novartis International ag
Domokos, Gabor
Switzerland, Basel
Novartis International ag
Roubert, Bernard
Switzerland, Basel
Novartis International ag
Rose, Christian Sainte
France, Lille
Hôpital Saint Vincent-de-paul Ghicl
Agaoglu, Leyla
Turkey, Istanbul
Istanbul Üniversitesi
Alimena, G.
Italy, Rome
Azienda Ospedaliera Universitaria Policlinico Umberto I
Alonso, D.
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Ame, S.
France, Strasbourg
Hopital de Hautepierre
Angelucci, Emanuele
Italy, Cagliari
Azienda Ospedaliera Brotzu - Businco
Arrizabalaga, B.
Spain, Baracaldo
Osakidetza, Cruces University Hospital
Athanasiou-Metaxa, Miranda
Greece, Thessaloniki
Aristotle University of Thessaloniki
Augustson, B.
Australia, Perth
Sir Charles Gairdner Hospital
Aydınok, Yeşim
Turkey, Izmir
Ege Üniversitesi
Baba, A.
Malaysia, Kota Bharu
Hospital Universiti Sains Malaysia
Baccarani, Michele
Italy, Malpighi
Az. Ospedaliera Di Bologna
Beck, J.
Germany, Mainz
Universitätsmedizin Mainz
Beris, Photis
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Beyne-Rauzy, Odile
France, Toulouse
Hôpital Purpan
Birgens, H.
Denmark, Herlev
Amtssygehusetl Herlev
B́ordessoule, Dominique
France, Limoges
Chu de Limoges
Borgna-Pignatti, C.
Italy, Cona
Azienda Ospedaliero-universitaria Di Ferrara
Bosly, André E.
Belgium, Dinant
Chu Dinant Godinne | Ucl Namur
Bouabdallah, Krimo
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Bowden, Donald K.
Australia, Clayton
Monash Medical Centre
Bowen, David T.
United Kingdom, Leeds
Leeds General Infirmary
Bron, Dominique G.
Belgium, Brussels
Institut Jules Bordet
Cappellini, Maria Teresa
Italy, Milan
Università Degli Studi Di Milano
Capra, Marcello
Italy, Palermo
Ospedale Civico M. Ascoli
Cartron, Guillaume
France, Le Mans
Clinique Victor Hugo
Cazzola, Mario
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Chalkias, C.
Greece, Larissa
Larissa General Hospital
Chan, Lee Lee
Malaysia, Kuala Lumpur
University of Malaya Medical Centre
Chancharunee, S.
Thailand, Bangkok
Ramathibodi Hospital
Chapman, C.
United Kingdom, Leicester
Leicester Royal Infirmary
Charoenkwan, P.
Thailand, Chaing Mai
Chiang Mai University
Chasapopoulou, E.
Greece, Thessaloniki
University General Hospital of Thessaloniki Ahepa
Cheze, S.
France, Caen
Hopital Clemenceau
Chuansumrit, Ampaiwan
Thailand, Bangkok
Ramathibodi Hospital
Cianciulli, P.
Italy, Rome
Ospedale S. Eugenio
Dauriac, C.
France, Rennes
Hôpital Pontchaillou
Delforge, Michel
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Dölken, G.
Germany, Greifswald
Universität Greifswald
Dombret, Hervé
France, Paris
Hôpital Saint-louis
Duyster, J.
Germany, Munich
Technische Universität München
Economopoulos, T.
Greece, Athens
School of Medicine
Ehninger, Gerhard E.
Germany, Dresden
Universitätsklinikum Carl Gustav Carus Dresden
ElAlfy, Mohsen Saleh
Egypt, Cairo
Ain Shams University
El-Beshlawy, Amal M.
Egypt, Giza
Cairo University
Enggaard, L.
Denmark, Hillerod
Nordsjællands Hospital - Hillerød
Fillet, G.
France, Bagnolet
Saft
Filosa, Aldo
Italy, Naples
Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli
Forni, G. L.
Italy, Genoa
E.o. Ospedali Galliera
Galanello, Renzo
Italy, Cagliari
Azienda Ospedaliera Brotzu - Microcitemico
Gastl, Günther A.
Austria, Innsbruck
Medizinische Universitat Innsbruck
Giraudier, Stéphane
France, Creteil
Hôpital Henri Mondor
Goldfarb, Ada W.
Israel, Jerusalem
Hadassah University Medical Centre
Grigg, Andrew P.
Australia, Melbourne
Royal Melbourne Hospital
Gumruk, Fatma
Turkey, Ankara
Hacettepe Üniversitesi
Ha, S. Y.
Hong Kong
Queen Mary Hospital Hong Kong
Haase, D.
Germany, Gottingen
Universitätsmedizin Göttingen
Heinrich, B.
Germany, Augsburg
Gemeinschaftspraxis Brudler/ Heinrich
Hertzberg, Mark
Australia, Sydney
Westmead Hospital
Ho, J.
Australia, Sydney
Royal Prince Alfred Hospital
Hsu, H. C.
Taiwan, Taipei
Taipei Veterans General Hospital
Huang, S.
China, Guangzhou
Guang Zhou Zhong Shan No.2 Hospital
Hunault-Berger, M.
France, Angers
Chu Angers
Inusa, Baba Psalm Duniya
United Kingdom, London
Evelina London Children's Healthcare
Jaulmes, Dominique
France, Paris
Hôpital Saint-antoine
Jensen, J.
Denmark, Aarhus
Aarhus Universitetshospital
Kattamis, Antonis C.
Greece, Athens
National and Kapodistrian University of Athens
Kılınç, Yurdanur
Turkey, Adana
Çukurova Üniversitesi
Kim, K. H.
South Korea, Seoul
Samsung Medical Center, Sungkyunkwan University
Kinsey, Sally E.
United Kingdom, Leeds
St James's University Hospital
Kjeldsen, L.
Denmark, Copenhagen
Rigshospitalet
Koren, Ariel
Israel, Afula
Emek Medical Center
Lai, M. E.
Italy, Cagliari
Azienda Ospedaliera Brotzu - Microcitemico
Lai, Yongrong
China, Nanjing
Nanjing Medical University
Lee, Jongwook
South Korea, Bucheon-si
The Catholic University of Korea
Lee, K. H.
South Korea, Seoul
Asan Medical Center
Lee, Szu Hee
Australia, Adelaide
Royal Adelaide Hospital
Legros, Laurence
France, Nice
Centre Hospitalier Universitaire de Nice, Hôpital L'archet
Li, C.
China, Guangzhou
Nanfang Hospital
Li, Chi Kong
Hong Kong
Prince of Wales Hospital Hong Kong
Li, Q.
China, Shanghai
Shanghai No.1 Hospital
Lin, Kai Hsin
Taiwan, Taipei
National Taiwan University Hospital
Linkesch, Werner M.
Austria, Graz
Lkh-universitätsklinikum Graz
Lübbert, M.
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Lutz, Dieter
Austria, Linz
A. Ö. Krankenhausder Elisabethinen
Mohamed Thalha, A. J.
Malaysia, Kuala Lumpur
Hospital Canselor Tuanku Muhriz Ukm
Mufti, Ghulam J.
United Kingdom, London
King's College Hospital
Muus, P.
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 176
Authors: 100
Affiliations: 96
Identifiers
Doi:
10.1016/j.leukres.2010.03.009
ISSN:
01452126
Study Design
Cohort Study