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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women
BMC Women's Health, Volume 12, Article 11, Year 2012
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Description
Background: Hypovitaminosis D is associated to accentuated bone loss. However, association between osteoporotic vertebral fractures (VFs) and vitamin D status has not been clearly established.Objective: To determine serum vitamin D status and to assess the association of vitamin D status with bone mineral density (BMD) and asymptomatic VFs prevalence using vertebral fracture assessment (VFA) in a cohort of Moroccan menopausal women.Methods: from June to September 2010, 178 menopausal women 50 years old and over were enrolled in this cross-sectional study. The mean ± SD (range) age, weight, height and BMI were 58.8 ± 8.2 (50 to 79) years, 73.2 ± 13.8 (35 to 119) Kgs, 1.56 ± 0.06 (1.43 - 1.79) m and 29.8 ± 5.9 (17.5 - 49.8) kg/m 2, respectively. VFA images and scans of the lumbar spine and proximal femur were obtained using a GE Healthcare Lunar Prodigy densitometer. VFs were defined using a combination of Genant semiquantitative approach and morphometry. Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured.Results: Among the 178 women, 45 (25.2%) had densitometric osteoporosis, and on VFA, VFs (grade 2 or 3) were detected in 20.2% while grade 1 were identified in 33.1%. The mean values of serum levels of 25(OH)D were 15.8 ± 11.6 ng/ml (range: 3.0 - 49.1) with 152 patients (85.3%) having levels <30 ng/ml (insufficiency) and 92 (51.6%) <10 ng/ml (deficiency). Stepwise regression analysis showed that presence of VFs was independently related to age, 25(OH)D and densitometric osteoporosis.Conclusion: our study shows that advanced age, hypovitaminosis D and osteoporosis are independent risk factors for asymptomatic VFs in Moroccan postmenopausal women. © 2012 El Maghraoui et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
El Maghraoui, Abdellah
Morocco, Agdal Rabat
Military Hospital Mohammed V
Ouzzif, Zohra
Morocco, Agdal Rabat
Military Hospital Mohammed V
Mounach, Aziza
Morocco, Agdal Rabat
Military Hospital Mohammed V
Rezqi, Asmaa
Morocco, Agdal Rabat
Military Hospital Mohammed V
Achemlal, Lahcen
Morocco, Agdal Rabat
Military Hospital Mohammed V
Bezza, Ahmed
Morocco, Agdal Rabat
Military Hospital Mohammed V
Tellal, Saida
Morocco, Agdal Rabat
Military Hospital Mohammed V
Dehhaoui, Mohammed
Morocco, Casablanca
Hassan Ii University of Casablanca
Ghozlani, Imad
Morocco, Agdal Rabat
Military Hospital Mohammed V
Statistics
Citations: 48
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1186/1472-6874-12-11
e-ISSN:
14726874
Research Areas
Health System And Policy
Noncommunicable Diseases
Violence And Injury
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Female