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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
False-positive rifampicin resistance on Xpert® MTB/RIF: Case report and clinical implications
International Journal of Tuberculosis and Lung Disease, Volume 16, No. 2, Year 2012
Notification
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Description
The World Health Organization had endorsed Xpert®MTB/RIF (Xpert) as the initial diagnostic for multidrug-resistant tuberculosis (TB) or TB suspects co-infected with the human immunodeficiency virus. We investigated an unexpected case of rifampicin (RMP) resistance on Xpert using repeat Xpert, smear microscopy, MTBDRplus assay, culture, drug susceptibility testing, spoligotyping and rpoB gene sequencing. A false-positive result was most likely, given the wild type rpoB gene sequence and exclusion of both mixed infection and mixture of drug-susceptible and drug-resistant populations. When decentralising Xpert, test performance characteristics need to be understood by health care workers and methods of confirmation of RMP resistance need to be accessible. © 2012 The Union.
Authors & Co-Authors
van Rie, Annelies
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mellet, K.
South Africa, Johannesburg
Right to Care
John, Melanie Anne A.
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Johannesburg
National Health Laboratory Service
Scott, Lesley Erica
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
University of the Witwatersrand
Page-Shipp, Liesl Shirley
South Africa, Johannesburg
Right to Care
Dansey, Heather
South Africa, Johannesburg
Witkoppen Health and Welfare Centre
Victor, Thomas Calldo
South Africa, Stellenbosch
Stellenbosch University
Warren, Robin Mark
South Africa, Stellenbosch
Stellenbosch University
Statistics
Citations: 55
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.5588/ijtld.11.0395
ISSN:
10273719
Research Areas
Genetics And Genomics
Infectious Diseases