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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Origin and spread of Bos taurus: New clues from mitochondrial genomes belonging to haplogroup T1
PLoS ONE, Volume 7, No. 6, Article e38601, Year 2012
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Description
Background: Most genetic studies on modern cattle have established a common origin for all taurine breeds in the Near East, during the Neolithic transition about 10 thousand years (ka) ago. Yet, the possibility of independent and/or secondary domestication events is still debated and is fostered by the finding of rare mitochondrial DNA (mtDNA) haplogroups like P, Q and R. Haplogroup T1, because of its geographic distribution, has been the subject of several investigations pointing to a possible independent domestication event in Africa and suggesting a genetic contribution of African cattle to the formation of Iberian and Creole cattle. Whole mitochondrial genome sequence analysis, with its proven effectiveness in improving the resolution of phylogeographic studies, is the most appropriate tool to investigate the origin and structure of haplogroup T1. Methodology: A survey of >2200 bovine mtDNA control regions representing 28 breeds (15 European, 10 African, 3 American) identified 281 subjects belonging to haplogroup T1. Fifty-four were selected for whole mtDNA genome sequencing, and combined with ten T1 complete sequences from previous studies into the most detailed T1 phylogenetic tree available to date. Conclusions: Phylogenetic analysis of the 64 T1 mitochondrial complete genomes revealed six distinct sub-haplogroups (T1a-T1f). Our data support the overall scenario of a Near Eastern origin of the T1 sub-haplogroups from as much as eight founding T1 haplotypes. However, the possibility that one sub-haplogroup (T1d) arose in North Africa, in domesticated stocks, shortly after their arrival from the Near East, can not be ruled out. Finally, the previously identified "African-derived American" (AA) haplotype turned out to be a sub-clade of T1c (T1c1a1). This haplotype was found here for the first time in Africa (Egypt), indicating that it probably originated in North Africa, reached the Iberian Peninsula and sailed to America, with the first European settlers. © 2012 Bonfiglio et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3369859/bin/pone.0038601.s001.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3369859/bin/pone.0038601.s002.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3369859/bin/pone.0038601.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3369859/bin/pone.0038601.s004.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3369859/bin/pone.0038601.s005.doc
Authors & Co-Authors
Bonfiglio, Silvia
Italy, Pavia
Università Degli Studi Di Pavia
Ginja, Catarina
Portugal, Lisbon
Universidade de Lisboa
de Gaetano, Anna Maria
Italy, Pavia
Università Degli Studi Di Pavia
Achilli, A.
Italy, Perugia
Università Degli Studi Di Perugia
Olivieri, Anna
Italy, Pavia
Università Degli Studi Di Pavia
Colli, Licia
Italy, Piacenza
Università Cattolica Del Sacro Cuore, Campus Di Piacenza e Cremona
Tesfaye, Kassahun
Ethiopia, Addis Ababa
Addis Ababa University
Agha, Saif Hassan
Egypt, Cairo
College of Agriculture
Gama, L. T.
Portugal, Lisbon
Universidade de Lisboa
Cattonaro, Federica
Italy, Udine
Institute of Applied Genomics Iga-cnr
Penedo, Maria Cecília Torres
United States, Davis
University of California, Davis
Ajmone-Marsan, Paolo
Italy, Piacenza
Università Cattolica Del Sacro Cuore, Campus Di Piacenza e Cremona
Torroni, Antonio
Italy, Pavia
Università Degli Studi Di Pavia
Ferretti, Luca
Italy, Pavia
Università Degli Studi Di Pavia
Statistics
Citations: 80
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1371/journal.pone.0038601
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Multi-countries
Egypt