Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Early archives of genetically-restricted proviral DNA in the female genital tract after heterosexual transmission of HIV-1
AIDS, Volume 21, No. 2, Year 2007
Notification
URL copied to clipboard!
Description
OBJECTIVES AND METHOD: In order to characterize human immunodeficiency virus type 1 (HIV-1) variants that are transmitted in women via heterosexual intercourse, the env V1-V3 sequences of HIV-1 provirus (DNA) and free virus (RNA) in paired samples of blood and cervicovaginal secretions of untreated chronically and primary infected African women were compared. RESULTS: Env RNA sequences retrieved from plasma and genital compartments formed a single cluster in primary infection. In contrast, env RNA sequences from these two compartments were distinct in chronically infected women. Analysis of proviral DNA of primary infected women showed that most HIV-1 sequences derived from the genital epithelia form independent clusters from HIV-1 sequences of DNA from peripheral blood mononuclear cells and RNA recovered from plasma and genital secretions. Similarly, the analysis of proviral DNA in the genital compartment of chronically infected women showed the persistence of genetically-restricted cluster of HIV-1. CONCLUSIONS: These observations indicate that a viral subpopulation is archived as proviral DNA in the female genital tract early in primary infection, and suggest that HIV-1 variants from the male donor are selected in the female mucosal site during male to female transmission of HIV-1. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Chomont, Nicolas
France, Paris
Université Paris Cité
France, Paris
Hôpital Européen Georges-pompidou
Hocini, Hakim
France, Paris
Université Paris Cité
France, Paris
Hôpital Européen Georges-pompidou
Grésenguet, Gérard
Central African Republic
Centre National de Référence Des Maladies Sexuellement Transmissibles et du Sida
Brochier-Armanet, Céline
France, Marseille
Aix Marseille Université
Bouhlal, Hicham
France, Paris
Université Paris Cité
France, Paris
Hôpital Européen Georges-pompidou
Andréoletti, Laurent
France, Reims
Chu de Reims
Becquart, Pierre
France, Montpellier
Ird Centre de Montpellier
Charpentier, Charlotte
France, Paris
Université Paris Cité
France, Paris
Hôpital Européen Georges-pompidou
de Dieu Longo, Jean
Central African Republic
Centre National de Référence Des Maladies Sexuellement Transmissibles et du Sida
Si-Mohamed, Ali
France, Paris
Université Paris Cité
France, Paris
Hôpital Européen Georges-pompidou
Kazatchkine, Michel Daniel
France, Paris
Université Paris Cité
France, Paris
Hôpital Européen Georges-pompidou
Bélec, Laurent
France, Paris
Université Paris Cité
France, Paris
Hôpital Européen Georges-pompidou
Statistics
Citations: 30
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1097/QAD.0b013e328011f94b
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Male
Female