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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Contribution of SELP and PSGL-1 genotypes and haplotypes to the presence of coronary heart disease in Tunisians
Molecular Biology Reports, Volume 38, No. 1, Year 2011
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Description
P-selectin (SELP) and its counter-receptor, P-selectin glycoprotein ligand-1 (PSGL-1), play key role in the transient attachment of leukocytes to endothelial cells predisposing to coronary heart disease (CHD). In the current report, 293 angiographically proven CHD patients and 327 age, gender, and race-matched controls were included. Our aim was to evaluate the contribution to CHD of the following SNPs: C-2123G, G-1969A and T715P in SELP, Met62Ile and the VNTR variants in PSGL-1 gene in a North African population from Tunisia. While there were no significant differences in the distribution of SELP or PSGL-1 alleles or genotypes between patients and controls, a trend for a significant association of the C-2123G genotypes distribution with incident CHD was observed (P = 0.06). Assuming an additive model of transmission, the risk was 74% higher among subjects carrying the GG genotypes in comparison to those carrying the CC genotype (OR = 1.74 [1.01-2.98], P = 0.04) and 80% higher in the recessive model (OR = 1.80 [1.08-3.01], P = 0.02). Haplotype analysis did not identify any specific SELP or PSGL-1 haplotypes to be associated with CHD. The present study demonstrated no evidence of association between individual SELP or PSGL-1 SNPs or haplotypes with incident CHD. However, this study replicates absence of association of the mostly studied SNP, T715P, previously reported in individuals with African origin. © 2010 Springer Science+Business Media B.V.
Authors & Co-Authors
Ghazouani, Lakhdar
Tunisia, Monastir
Research Unit of Biology and Genetics of Cancer
Abboud, Nesrine
Tunisia, Monastir
Research Unit of Biology and Genetics of Cancer
Khalifa, Sonia Ben Hadj
Tunisia, Monastir
Research Unit of Biology and Genetics of Cancer
Perret, Claire
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Nicaud, Viviane
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Almawi, Wassim Y.
Bahrain, Manama
Arabian Gulf University
Cambien, François A.
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Mahjoub, Touhami
Tunisia, Monastir
Research Unit of Biology and Genetics of Cancer
Statistics
Citations: 15
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1007/s11033-010-0133-z
ISSN:
03014851
e-ISSN:
15734978
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Tunisia