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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania
Journal of Infectious Diseases, Volume 202, No. 10, Year 2010
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Description
Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV-1 infection, remains understudied. African-specific allele HLA-A*74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14-0.80; P = .011) and with protection from CD4+ cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07-0.91; P = .032) and men (OR, 0.15; 95% CI, 0.01-0.78; P = .020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Koehler, Rebecca N.
Unknown Affiliation
Walsh, A. M.
Unknown Affiliation
Saathoff, Elmar
Unknown Affiliation
Tovanabutra, Sodsai
Unknown Affiliation
Arroyo, Miguel A.
Unknown Affiliation
Currier, Jeffrey R.
Unknown Affiliation
Maboko, Leonard L.
Unknown Affiliation
Hoelsher, Michael
Unknown Affiliation
Robb, Merlin Lee
Unknown Affiliation
Michael, Nelson L.
Unknown Affiliation
McCutchan, Francine E.
Unknown Affiliation
Kim, Jerome Hahn
Unknown Affiliation
Kijak, Gustavo Hernán
Unknown Affiliation
Statistics
Citations: 40
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1086/656913
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Case-Control Study
Study Locations
Tanzania
Participants Gender
Male
Female