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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Multiple episodic evolution events in v1r receptor genes of East-African cichlids
Genome Biology and Evolution, Volume 6, No. 5, Year 2014
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Description
Fish use olfaction to detect a variety of nonvolatile chemical signals, and thus, this sense is key to survival and communication. However, the contribution of the olfactory sense to social especially reproductive interactions in cichlids is still controversial. To obtain insights into this issue, we investigated the genes encoding Vi Rs possible candidates for reproductive pheromone receptors among East-African cichlids. Interestingly, we found an excess of nonsynonymous over synonymous substitutions in four of six Vi R genes in multiple cichlid lineages. First, we found that highly dimorphic V1R2 allele groups were shared among the cichlids inhabiting all East-African Great Lakes emerged through the episodic accumulation of the nonsynonymous substitutions prior to the radiation of the Lake Tanganyika species flock. We further detected such episodic events in Vi Ri of the tribe Tropheini, and in Vi R3 and V1R6 of the tribe Trematocarini. The excess of nonsynonymous substitutions in these examples were indicated as dNIdS> 1, which were all statistically significant by Fisher's exact test. Furthermore, we speculate that the amino acid changes in these episodic events are likely functional switch because they occurred in the putative ligand-binding pocket. Our finding of the occurrence of multiple episodic events and the unexpected gene diversity in one unique gene family is suggestive of the contribution of the Vi R to the species diversification and the social interaction in cichlids. © 2014 The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4040994/bin/supp_6_5_1135__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4040994/bin/supp_evu086_STables.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC4040994/bin/supp_evu086_Supplementary_materials.pptx
Authors & Co-Authors
Nikaido, Masato
Japan, Tokyo
Tokyo Institute of Technology
Ota, Tomoki
Japan, Tokyo
Tokyo Institute of Technology
Hirata, Tadashi
Japan, Tokyo
Tokyo Institute of Technology
Suzuki, Hikoyu
Japan, Tokyo
Tokyo Institute of Technology
Satta, Yoko
Japan, Hayama
The Graduate University for Advanced Studies
Aibara, Mitsuto
Japan, Tokyo
Tokyo Institute of Technology
Japan, Tsukuba
Foundation for Advancement of International Science
Mzighani, Semvua Isa
Japan, Tokyo
Tokyo Institute of Technology
Tanzania, Dar es Salaam
Tanzania Fisheries Research Institute Tafiri
Sturmbauer, Christian
Austria, Graz
Institut Fur Zoologie Der Karl-franzens Universitat Graz
Hagino-Yamagishi, Kimiko
Japan, Tokyo
Tokyo Metropolitan Institute of Medical Science
Okada, Norihiro
Japan, Tokyo
Tokyo Institute of Technology
Japan, Tsukuba
Foundation for Advancement of International Science
Taiwan, Tainan
National Cheng Kung University
Statistics
Citations: 23
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1093/gbe/evu086
e-ISSN:
17596653
Research Areas
Cancer
Genetics And Genomics
Sexual And Reproductive Health