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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High prevalence of hepatitis B, C, and E markers in young sexually active adults from The Central African Republic
Journal of Medical Virology, Volume 46, No. 3, Year 1995
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Description
The Central African Republic is located in tropical Africa, where both the human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are highly endemic. The exact prevalence of hepatitis C virus (HCV) and hepatitis E virus (HEVI markers in this country is unknown. The aim of the study was to determine, according to HlV and HBV serostatus, the prevalence of these markers in young sexually active adults in the Central African Republic. One hundred and fifty‐seven consecutive patients attending the National Centre for Sexually Transmitted Diseases in Bangui were included. The following serological markers were examined: (i) anti‐HIV1 and anti‐HIV2 antibodies; (ii) markers of HBV infection; (iii) anti‐HCV antibodies; (iv) anti‐HEV antibodies. Anti‐HIV1 antibodies were found in 31 of the 157 patients (20%). The prevalence of anti‐HBc antibodies, reflecting exposure to HBV, was 140/157 (89%) and 45 had detectable anti‐HBs antibodies. Twenty‐two patients (14%) were chronic carriers of hepatitis B surface antigen (HBsAg), but only one was HBe antigen‐positive. Anti‐HCV antibodies were found in 8 persons (5%) and antiHEV antibodies in 38 (24%). No difference was found in the prevalence of these markers according to the presence or absence of anti‐HIV antibodies. This study confirms the high rate of HIV infection, HBV exposure and chronic carriage of HBsAg in sexually active young adults in the Central African Republic. A high prevalence of HCV markers was found in this population, similar to that reported in neighbouring countries, together with a high rate of HEV markers, suggesting that HEV is endemic in this region. © 1995 Wiley‐Liss, Inc. Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Pawlotsky, Jean Michel
France, Paris
Université Paris Cité
Bélec, Laurent
France, Paris
Hopital Broussais
Grésenguet, Gérard
Central African Republic
National Center for Sexually Transmitted Diseases
Deforges, Lionel
France, Paris
Université Paris Cité
Bouvier, Magali
France, Paris
Université Paris Cité
Duval, Jean
France, Paris
Université Paris Cité
Dhumeaux, Daniel
France, Paris
Université Paris Cité
Statistics
Citations: 88
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.1890460318
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Central African Republic